A Study of AK129 With or Without AK117 in PD(L)1-refractory Classic Hodgkin Lymphoma
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: AK129, AK117.
- Кому может быть актуально
- Состояния в реестре: Classic Hodgkin Lymphoma. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
A Phase I/II Study of AK129 (Bispecific Antibody Targeting LAG-3 and PD-1) Monotherapy or in Combination With AK117 (Anti-CD47 Monoclonal Antibody) in Relapse or Refractory Classic Hodgkin Lymphoma With PD-1/L1 Inhibitor Treatment Failure
Обзор
This is a phase I/II study. All subjects are patients diagnosed with relapse or refractory (R/R) classic Hodgkin lymphoma (cHL) and has progressed on treatment with PD-1/L1 inhibitor therapy. The purpose of this study is to evaluate the safety and efficacy of AK129 (bispecific antibody targeting LAG-3 and PD-1) monotherapy or in combination with AK117 (anti-CD47 monoclonal antibody) in R/R cHL with PD-1/L1 inhibitor treatment failure.
Вмешательства
- Препарат AK129
Subjects receive AK129 intravenously. - Препарат AK117
Subjects receive AK117 intravenously.
Первичные конечные точки
- Phase I: Number of participants with dose limiting toxicity (DLT) [Срок оценки: Within the first 28 days following the first dose of study treatment.]
- Phase I/II: Incidence and severity of adverse events (AEs) [Срок оценки: Up to approximately 2 years.]
- Phase I/II: Objective response rate (ORR) [Срок оценки: Up to approximately 2 years]
Вторичные конечные точки (10)
- Disease control rate (DCR) [Срок оценки: Up to approximately 2 years]
- Time to response (TTR) [Срок оценки: Up to approximately 2 years]
- Duration of response (DoR) [Срок оценки: Up to approximately 2 years]
- Progression-free survival (PFS) [Срок оценки: Up to approximately 2 years]
- Overall survival (OS) [Срок оценки: Up to approximately 2 years]
- Maximum concentration (Cmax) [Срок оценки: Up to approximately 2 years]
- Time to maximum concentration (Tmax) [Срок оценки: Up to approximately 2 years]
- Area under the curve (AUC) [Срок оценки: Up to approximately 2 years]
- Half-life (T1/2) [Срок оценки: Up to approximately 2 years]
- Anti-drug antibody (ADA) [Срок оценки: Up to approximately 2 years]
Критерии участия
Критерии включения
- Age ≥ 18 years old at the time of enrolment.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Expected Survival of ≥ 12 weeks.
- Diagnosed as R/R cHL according to Lugano 2014 criteria.
- Has progressed on treatment with PD-1/L1 inhibitior therapy.
- Has adequate organ function.
- All female and male subjects of reproductive potential must agree to use an effective method of contraception from the start of screening until 120 days after the last dose of study treatment.
Критерии исключения
- Diagnosed with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or gray zone lymphoma.
- Central nervous system (CNS) lymphoma involvement.
- Known history of human T-cell leukemia virus type 1 (HTLV-1) infection.
- Autologous hematopoietic stem cell transplantation (auto-HSCT) or chimeric antigen receptor T cell immunotherapy (CAR-T) within 90 days prior to the first dose of study treatment.
- Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Previous use of any agents targeting the CD47-SIRPα pathway, LAG-3 pathway, or similar targets.
- Has other malignancies within 3 years prior to the first dose or residual lesions from other malignancies diagnosed more than 3 years ago.
- Has an active autoimmune disease requiring systemic treatment within 2 years prior to the first dose.
- History of active or previously confirmed inflammatory bowel disease.
- History of interstitial lung disease requiring corticosteroid therapy, or current interstitial lung disease.
- Has known active Hepatitis B or Hepatitis C.
- Unresolved toxicity from previous anti-tumor treatment.
- Uncontrolled comorbidities.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Распределение
- Нерандомизированное
- Модель
- Одна группа
- Маскирование
- Открытое
- Основная цель
- Лечение
Центры проведения
Китай · 1 центр
- Beijing Cancer Hospital — Пекин
Идентификаторы
NCT: NCT06642792 · AK129-102