Unlock the Secrets of Ageing Brains Through P300 Brain-computer Interface Games

Официальное название

Effects of Different Parameter Settings on the Classification Accuracy of P300-BCI Speller in Elderly Adults with and Without Mild Cognitive Impairments

Обзор

The study will investigate the use of Electroencephalography (EEG) in understanding mild cognitive impairment (MCI). EEG is commonly used in everyday clinical practice for the assessment of a wide range of neurological disorders. It records the brains spontaneous electrical signals and offers a non-invasive means of visually evaluating brain signals. By analysing these signals, we aim to uncover invaluable insights into cognitive impairments and the ageing brains cognitive processes.

Подробное описание

The Electroencephalogram (EEG) is widely used in clinical practice to assess various neurological disorders. It records the brains spontaneous electrical activity, providing a non-invasive way to visually examine brain signals. By analysing these signals, we aim to gain valuable insights into cognitive impairments and the cognitive processes of the ageing brain. The P300 is an event-related potential (ERP) that serves as a crucial EEG-based biomarker, whose amplitude and latency are key points of research in cognitive impairments. Typically elicited by a visual speller, the P300 could be used for the communication through brain-computer interface (BCI). A P300-based BCI enables communication by detecting the P300 response to specific target letters, allowing users to select letters they wish to spell through interactive interface. In this study, we will recruit 15 elderly participants with mild cognitive impairment (MCI) symptoms and 15 controls without MCI. We will customise the P300-BCI by adjusting the inter-stimulus interval (ISI) and the matrix size which is the probability of the target presenting. This will help us investigate how these parameter settings influence the P300 components and the accuracy of the P300-BCI in both groups. Additionally, this study could help explore the potential of the P300-BCI to mitigate MCI symptoms and provide evidence for its further development.

Вмешательства

• Диагностический тест MoCA Test
  MoCA (Montreal Cognitive Assessment or The MoCA Test) was validated as a highly sensitive tool for early detection of mild cognitive impairment (MCI) in hundreds of peer-reviewed studies since 2000. MoCA has been widely adopted in clinical settings and used in academic and non-academic research around the world. The sensitivity of MoCA for detecting MCI is 90%, compared to 18% for the MMSE. Prospective participants meeting the eligibility criteria, as determined by the Montreal Cognitive Assessm
• Устройство Random Dot Motion (RDM) task
  Random Dot Motion task (RDM) has been widely used in research on spatial attention, and decision-making ability, etc., and its results (accuracy and reaction time) can be used as indicators to detect spatial attention. During the assessment, participants were required to monitor a series of dots in constant random motion on the screen. The dots sometimes moved coherently together to the left or right, and participants were required to press the left mouse button when they perceived them moving t
• Устройство P300-BCI task without feedback
  Two different speller matrix sizes: 3×3 and 5×5, two inter-stimulus intervals (ISIs): 117ms (i.e., commonly used ISI for healthy adults) and 175ms (i.e., 50% longer than the widely used ISI) and two spelling words (QUICK and JUMP) are designed in this experiment to explore the calibration accuracy of these eight parameter combinations in the young and old groups and obtain the best parameter combination. The matrix contains letters and digits, and the target letters will be displayed below the m

Первичные конечные точки

• Accuracy of the Brain-Computer Interface (BCI) model across different settings which is being tested [Срок оценки: Through study completion, an average of 9 months.]

Вторичные конечные точки (6)

• The scores of the Montreal Cognitive Assessment (MoCA) [Срок оценки: Through study completion, an average of 9 months.]
• Reaction times of the Random Dot Motion (RDM) test [Срок оценки: Through study completion, an average of 9 months.]
• Error rates of the Random Dot Motion (RDM) test [Срок оценки: Through study completion, an average of 9 months.]
• Characteristics of the P300 amplitude across different settings [Срок оценки: Through study completion, an average of 9 months.]
• Characteristics of the P300 latency across different settings [Срок оценки: Through study completion, an average of 9 months.]
• Answers to the two questionnaires, using a 10-point rating scale [Срок оценки: Through study completion, an average of 9 months.]

Критерии участия

Критерии включения

• Diagnosed with mild cognitive impairments (MCI) or mild dementia
• Normal or corrected-to-normal vision
• Can maintain sitting with or without support for around 60 minutes continuously
• Cognitive and language abilities to understand and participate in the study protocol and able to give consent and understand instructions

Критерии исключения

• Severe cognitive impairment that would interfere with their ability to comply with the experimental protocol or provide informed consent
• Pre-existing severe systemic disorders like active cancer, end-stage pulmonary or cardiovascular disease, psychiatric illness including severe alcohol or drug abuse
• Past history of epilepsy- with seizures in last 12 months
• History of photosensitive epilepsy.
• Allergy to latex

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Великобритания · 1 центр

• The University of Sheffield — Sheffield

Идентификаторы

NCT: NCT06628427 · IRAS346367

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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