Effect of Two Years of Resistance Training on Health Status in Postmenopausal Women: Longitudinal Study Active Aging.

Официальное название

Effect of Two Years of Resistance Training on Muscular Strength, Body Composition, Functional Fitness, Metabolic Biomarkers, Cognition, and Cardiac Parameters in Postmenopausal Women: Longitudinal Study Active Aging

Обзор

Aging is a natural process of the life cycle that can result in morphological, neuromuscular, metabolic, physiological, cognitive and behavioral changes that can compromise quality of life, autonomy, self-esteem, health and life expectancy, especially in the elderly. On the other hand, resistance training (RT) has been widely recommended for the elderly population, due to the numerous health benefits it brings, such as increased strength and muscle mass, reduced body fat, increased bone mineral content and density, and improved cardiometabolic profile, among others. However, the effectiveness of RT in attenuating or reversing the deleterious effects of aging has been analyzed by studies conducted, in most cases, over relatively short periods, i.e., eight to 24 weeks. Considering that recent investigations have demonstrated a wide variation in the adaptive responses to RT in this population, it is likely that many of these responses are time-dependent. Additionally, the influence of important mediators and moderators in this process, especially training intensity and volume, dietary habits, the presence or absence of diseases and degenerative processes that cause disability, and the use of polypharmaceuticals, has not yet been well established. Therefore, based on the Active Aging Longitudinal Study, a research project initiated in 2012, it is intend to analyze whether or not RT practice can produce positive and lasting adaptive responses on muscle strength, body composition, functional fitness, cognition, cardiometabolic biomarkers, and cardiac function in postmenopausal women, based on a randomized controlled clinical trial over a long period of time (two years). In addition, mediation and moderation analyses will be used to understand the real impact of RT on the outcomes to be analyzed.

Вмешательства

• Другое Exercise
  the RT program will consist of eight exercises for different body segments, namely: vertical bench press, horizontal leg press, low row, leg extension, scott curl, leg curl, triceps pulley and seated calf raise. Every 12 weeks of training, the program will be restructured with changes in the order in which the exercises are performed, the number of sets, the number of repetitions or the training system in an attempt to avoid a supposed adaptive plateau. The protocols in each stage will follow th
• Другое Control-no treatment
  Participants will maintain their daily activities.

Первичные конечные точки

• Body Fat [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Muscle mass [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]

Вторичные конечные точки (9)

• Cardiovascular risk factors [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Cardiac function [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• MoCA [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Stroop test [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Set shifting [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Verbal fluency tasks [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Depressive symptoms [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Anxiety symptoms [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]
• Bone [Срок оценки: from begining (November 2023) to the end 48 weeks of resistance training (November 2026)]

Критерии участия

Критерии включения

• 60 years of age or older;
• physically independent;
• not have cardiovascular, musculoskeletal or metabolic limitations that prevent the practice of physical exercises or the execution of motor tests;
• not being on hormone replacement therapy;
• not being involved in physical exercise more than once a week, over the six months prior to the start of the study.

Критерии исключения

• not participating in at least 85% of the training and not attending the assessments.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Профилактика

Центры проведения

Бразилия · 1 центр

• State University of Londrina — Londrina

Публикации

• Nabuco HCG, Tomeleri CM, Sugihara Junior P, Fernandes RR, Cavalcante EF, Antunes M, Ribeiro AS, Teixeira DC, Silva AM, Sardinha LB, Cyrino ES. Effects of Whey Protein Supplementation Pre- or Post-Resistance Training on Muscle Mass, Muscular Strength, and Functional Capacity in Pre-Conditioned Older Women: A Randomized Clinical Trial. Nutrients. 2018 May 3;10(5):563. doi: 10.3390/nu10050563. PMID 29751507
• Dos Santos L, Cyrino ES, Antunes M, Santos DA, Sardinha LB. Sarcopenia and physical independence in older adults: the independent and synergic role of muscle mass and muscle function. J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):245-250. doi: 10.1002/jcsm.12160. Epub 2016 Nov 8. PMID 27897417

Идентификаторы

NCT: NCT06621368 · GEPEMENE 2024b

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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