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Идёт набор NCT06608680

Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks

Без фазы С лечением Reading Language Control Subjects

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: iTBS, cTBS, Sham Stimulation.
Кому может быть актуально
Состояния в реестре: Reading, Language, Control Subjects. Базовые параметры: 18 лет — 30 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
США
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Systems

Обзор

The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are: 1. At what point after stimulation are the greatest effects on behavior seen 2. How excitatory and inhibitory stimulation affect behavior Researchers will compare stimulation types against a sham condition to see effects on reading and language behavior. Participants will be asked to * undergo reading, language, and cognitive testing * receive an MRI * receive TMS stimulation * perform language, reading, and motor tasks

Вмешательства

  • Поведенческое iTBS
    Excitatory stimulation of supramarginal gyrus
  • Поведенческое cTBS
    Inhibitory stimulation to supramarginal gyrus
  • Поведенческое Sham Stimulation
    Sham stimulation of supramarginal gyrus

Первичные конечные точки

  • Phonological Decoding Reaction Time [Срок оценки: Four time points after each stimulation (20, 40, 60 and 80 minutes after stimulation)]

Критерии участия

Критерии включения

  • Subjects must have a minimum of low average intellectual functioning (\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included.
  • Within a normal range of reading skills as \>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)
  • Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.
  • Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.
  • Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.
  • The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.
  • Individuals who have hearing deficits (\>25dB at 500+ Hz), visual deficits (\>20/40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.
  • Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.
  • Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.
  • Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Рандомизированное
Модель
Факторный дизайн
Маскирование
Двойное слепое
Основная цель
Фундаментальное исследование

Центры проведения

США · 1 центр
  • Georgia State University — Atlanta

Идентификаторы

NCT: NCT06608680 · H23282

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗