Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity

Официальное название

The Effect of Cycling Priming Coordination Training on Ataxia and Brain Plasticity

Обзор

Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to improving mobility and reducing the burden on caregivers. However, evidence-based rehabilitation approaches for ataxia remain limited. Recent studies suggest that improvements in motor learning are often accompanied by changes in cortical excitability. Abnormal cortical excitability in SCA patients may hinder rehabilitation efforts, yet priming strategies-such as exercise or specific stimuli-have been shown to enhance motor learning by modulating cortical excitability. Cycling exercise, in particular, has demonstrated the potential to improve coordination and influence cortical plasticity in individuals with SCA, making it a promising priming strategy for coordination training. This clinical trial aims to: 1. Investigate the priming effect and neural mechanisms of acute cycling exercise on coordination training in patients with SCA. 2. Explore the long-term impact of priming cycling training on cortical plasticity and functional mobility in individuals with SCA. This study seeks to provide insights into optimized rehabilitation interventions that could enhance the quality of life and independence for people with SCA.

Вмешательства

• Процедура Cycling Training
  Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conducted three times per week, over a period of two weeks.

Первичные конечные точки

• Overall Response Time [Срок оценки: Baseline, 2 weeks and 4 weeks]
• Overall Error Rate [Срок оценки: Baseline, 2 weeks and 4 weeks]
• Motor Evoked Potentials (MEPs) [Срок оценки: Baseline, 2 weeks and 4 weeks]
• Intracortical Facilitation (ICF) [Срок оценки: Baseline, 2 weeks and 4 weeks]
• Intracortical Inhibition (ICI) [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Total Scale for the Assessment and Rating of Ataxia (SARA) Score [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Total Berg Balance Scale (BBS) Score [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Total Time to Complete the Time Up and Go test (TUG test) [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Walking Speed [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Step Length [Срок оценки: Baseline, 2 weeks, and 4 weeks]

Вторичные конечные точки (6)

• Gait Speed Measurement Using 10-Meter Walk Test (10MWT) [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Double Support Time [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Single Support Time [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Swing Time [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Stance Time [Срок оценки: Baseline, 2 weeks, and 4 weeks]
• Cadence [Срок оценки: Baseline, 2 weeks, and 4 weeks]

Критерии участия

Критерии включения

\- Clinical diagnosis of SCA.

Критерии исключения

• Musculoskeletal injuries on legs
• Osteoporosis.
• Any peripheral or central nervous system injury or disease patients.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Тайвань · 1 центр

• Chang Gung University — Taoyuan

Идентификаторы

NCT: NCT06600269 · SCA_001

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗