The Effects of Ketone Ester Supplementation During a 5 Week Live High, Train Low Altitude Training Camp

Обзор

This study aims to investigate the effects of post-exercise and pre-sleep exogenous ketosis via oral ketone ester supplementation during a 5 week simulated altitude training camp.

Подробное описание

Altitude training camps, where you train at sea level but live at altitude, have become a popular way for athletes to prepare for upcoming races or events. The main aim of such training camps is to benefit from the adaptations following prolonged hypoxic exposure (increased EPO concentrations leading to an increase in oxygen carrying capacity in the blood). Recently, ketone bodies have been shown to cause similar adaptations. Therefore, this study aims to investigate whether the combination of exogenous ketosis and an altitude training camp is more beneficial compared to an altitude training camp on its own.

Participants will follow a 5 week simulated altitude training camp where they spend 75 hours per week at altitude (2000-3000 meters), while taking ketone or placebo supplements after every training sessions and before going to sleep. During these 5 weeks, they will adhere to a prescribed training plan, consisting of 5 to 7 training sessions per week. Before, after and 1 week after the training camp, their exercise performance, EPO concentrations, hemoglobin mass and VO2max will be tested.

Вмешательства

• Пищевая добавка Placebo supplement
  oral supplement containing: 16.4 grams of medium chained triglycerides, 1mM or sucrose octaacetate and water
• Пищевая добавка Ketone ester supplement
  Oral supplement containing: 25 grams of pure (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate ketone monoester drink

Первичные конечные точки

• Total hemoglobin mass [Срок оценки: Day 0, Day 35, Day 42]
• Skeletal muscle capillarization [Срок оценки: Day 0, Day 35, Day 42]
• Cycling exercise performance [Срок оценки: Day 0, Day 35, Day 42]

Вторичные конечные точки (4)

• Maximal oxygen uptake (VO2max) [Срок оценки: Day 0, Day 35, Day 42]
• Change in peripheral blood flow [Срок оценки: Day 0, Day 35, Day 42]
• Serum EPO concentrations [Срок оценки: Day 0, day1, week1, week2, week3, week4, week5, day35, day42]
• Sleep Architecture [Срок оценки: Day 0, day1, week 3, day35, day42]

Критерии участия

Критерии включения

• Physically fit and regularly involved in physical activity (2-5h per week)
• Good health status confirmed by a medical screening
• Non-smoking

Критерии исключения

• Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise
• Any kind of injury/pathology that is a contra-indication for exposure to hypoxia
• Ongoing pregnancy or breastfeeding
• intake of any medication or nutritional supplement that is proven to affect exercise performance during the last month prior to the start of the study
• Involvement in elite athletic training at a semi-professional or professional level
• Exposure to altitudes higher than 1500 m during the 3 months prior to the start of the study
• Blood ferritin levels below 30 ng/mL
• Current participation in another research trial
• Any other argument to believe that the subject is unlikely to succesfully complete the full study protocol

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Фундаментальное исследование

Центры проведения

Бельгия · 1 центр

• KU Leuven — Leuven

Идентификаторы

NCT: NCT06596083 · S67562

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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