Effect of Combined Exercise Training in Patients With Multiple Sclerosis

Официальное название

Investigation of the Effect of Exercise Training in Patient With Sarcopenic Multiple Sclerosis

Обзор

The aim of this clinical trial is exercise in sarcopenic MS patients to demonstrate the effectiveness of education. The main questions it aims to answer are: -Can exercise training make a change in muscle thickness in sarcopenic MS patients? --Does exercise training have an effect on balance in sarcopenic MS patients? \- Does exercise training have an effect on the risk of falling in sarcopenic MS patients? Participants will: They will continue combined exercise applications 3 days a week for 8 weeks. Evaluations will be made before the application and at the end of the 8 weeks. The data will be analyzed afterwards.

Подробное описание

A significant decrease in physical performance is observed in MS patients. The reasons for this can be changes in muscle contractile structures and symptoms such as sarcopenia. Sarcopenia is a disorder characterized by loss of skeletal muscle mass and decrease in muscle strength and physical performance. Loss of muscle mass seen outside of old age is defined as secondary sarcopenia. In recent years, studies on neurological disorders and their relationship with sarcopenia have increased. Early diagnosis of sarcopenia in neurological patients and implementation of applications aimed at this are important from an early stage. The aim of this study is to examine the effect of exercise training in sarcopenic MS patients. In the study, participants will be applied a combined exercise program 3 days a week for 8 weeks. Parameters such as muscle thickness, balance, and fall risk will be evaluated before and after physiotherapy application including aerobic exercise, balance exercises, and strengthening exercises.

Вмешательства

• Другое Exercise
  Participants in the experimental group will receive treatment for 8 weeks, 3 sessions per week. Each treatment session will be planned to last 60 minutes. People in the experimental group will receive a combined exercise training consisting of aerobic exercise, balance exercise and strengthening exercises for 8 weeks.
• Другое Home program
  The control group will be followed with a home program for 8 weeks. Patients will be asked to apply the home program, which includes traditional physiotherapy practices, 3 days a week and this will be followed by physiotherapists.

Первичные конечные точки

• Muscle thickness [Срок оценки: 8 weeks]

Вторичные конечные точки (7)

• SARC -F [Срок оценки: 8 weeks]
• Hand grip strength measurement [Срок оценки: 8 weeks]
• Bioelectrical impedance analysis [Срок оценки: 8 weeks]
• Timed Up and Go (TUG) [Срок оценки: 8 weeks]
• Berg Balance Scale (BBS) [Срок оценки: 8 weeks]
• Fatigue Severity Scale (FSS) [Срок оценки: 8 weeks]
• 6 Minute Walk Test [Срок оценки: 8 weeks]

Критерии участия

Критерии включения

• People diagnosed with MS by a neurologist
• People with ambulation whose EDSS is 4.5 or below
• People between the ages of 18-50
• People who do not exercise regularly and are not included in an exercise program

Критерии исключения

• Having been diagnosed with sarcopenia before MS diagnosis
• Having had an MS attack within the last 30 days
• Having any musculoskeletal problems that may affect walking and balance
• Having a diagnosed psychiatric disease that may affect cognitive status
• Having a neurological disease other than MS

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT06595394 · sarcopenicms11

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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