The Relationship Between Upper Extremity Function and Balance and Functional Mobility in Parkinson's Disease

Официальное название

Investigation of the Relationship Between Upper Extremity Function and Balance and Functional Mobility in Parkinson's Disease

Обзор

Parkinson's Disease (PD) is the second most common neurodegenerative disease, affecting 2-3% of the population aged 65 and over, characterized by the loss of dopaminergic neurons. The basal ganglia play a significant role in the pathogenesis of PD. The lesions of the basal ganglia impair the ability of patients to perform complex, goal-oriented, and skill-requiring movements. Consequently, motor symptoms such as bradykinesia, rigidity, hypokinesia, and tremor, which are progressively worse, are added to the clinical picture of the disease. These symptoms, which cause movement and activity limitations in individuals with PD, also affect upper extremity functions, balance, and functional mobility. Impairment of upper extremity functions, commonly seen from the early stages of the disease, can affect many basic activities of daily living, including buttoning clothes, tying shoelaces, sewing, writing, eating, and using various modern devices. Balance and mobility disorders are among the most debilitating features of the disease, as they lead to the deterioration of physical functions in PD. Balance and mobility issues in PD are identified as key determinants of the increasing fear of falling and the resulting decline in quality of life. Various factors such as rigidity, bradykinesia, impaired postural adjustments, and decreased sensory integration contribute to the negative impact on balance and mobility in individuals with PD. Proper balance and mobility performance are achieved through synergistic control during both dynamic and static postures between proximal body segments such as the trunk, spine, and pelvis. This contributes to the mobility of distal segments and the functionality of the upper extremities. Additionally, the contribution of upper extremity functions to balance and mobility has been demonstrated in healthy populations. Current literature also reveals that treatment programs targeting the upper extremities can improve mobility and balance, especially in neurological patient populations. In conclusion, balance and mobility disorders in Parkinson's disease can reduce proximal stability and affect hand dexterity. This study aims to examine the relationship between hand dexterity, balance, and functional mobility in individuals with PD.

Подробное описание

According to the sample size calculation, at least 26 diagnosed PD will be included. Participants' demographic characteristics will be taken initially and the stage will be recorded according to the Hoehn and Yahr Scale. Then, upper extremity functions, balance, and functional mobility will be evaluated.

Первичные конечные точки

• The Nine-Hole Peg Test [Срок оценки: Assessment will be conducted immediately after enrollment.]
• The Berg Balance Scale [Срок оценки: Assessment will be conducted immediately after enrollment.]
• The Timed Up and Go Test [Срок оценки: Assessment will be conducted immediately after enrollment.]
• The timed 360° turn test [Срок оценки: Assessment will be conducted immediately after enrollment.]
• Functional Reach Test [Срок оценки: Assessment will be conducted immediately after enrollment.]

Критерии участия

Критерии включения

• Having accepted participation in the study after being provided with detailed information about the research
• Having been diagnosed with only Parkinson's Disease by a specialist physician
• Having a Standardized Mini-Mental Test score greater than 24
• Being in stages 1 to 3 according to the Hoehn and Yahr Scale

Критерии исключения

• Having any vision, hearing, or perceptual issues that could affect the research outcomes
• Having an orthopedic problem in the upper extremity that could impact hand dexterity, balance, or mobility
• Having a cardiovascular, pulmonary, or hormonal disorder

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Случай-контроль

Центры проведения

Turkey (Türkiye) · 1 центр

• Sivas Cumhuriyet University — Sivas

Публикации

• Milosevic M, McConville KM, Masani K. Arm movement improves performance in clinical balance and mobility tests. Gait Posture. 2011 Mar;33(3):507-9. doi: 10.1016/j.gaitpost.2010.12.005. Epub 2011 Jan 11. PMID 21227695
• Kalkan AC, Kahraman T, Ugut BO, Colakoglu BD, Genc A. A comparison of the relationship between manual dexterity and postural control in young and older individuals with Parkinson's disease. J Clin Neurosci. 2020 May;75:89-93. doi: 10.1016/j.jocn.2020.03.018. Epub 2020 Mar 20. PMID 32201026

Идентификаторы

NCT: NCT06591975 · PD-hand-balance-mobility

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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