Cognitive-motor Training in Parkinson Disease

Официальное название

Cognitive-motor Training on Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson Disease

Обзор

Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.

Вмешательства

• Другое Cognitive-motor training
  Cognitive-motor training is that cognitive tasks incorporated into motor tasks.
• Другое Conventional physiotherapy
  Conventional physiotherapy includes stretching, ROM exercise, strengthening exercise, and eye-hand coordination.

Первичные конечные точки

• Gait variability [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Gait speed [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Step length [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Step width [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Single support time [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Double support time [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Frontal Assessment Battery [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Stroop color and word test [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Digit span test [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Event-related potential - N2 [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]

Вторичные конечные точки (4)

• Mini-Balance Evaluation Systems Test [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Montreal Cognitive Assessment [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Timed up and go test [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]
• Parkinson Disease Questionnaire [Срок оценки: Before and after 8 weeks of intervention, as well as 4 weeks after intervention]

Критерии участия

Критерии включения

• Diagnoses of idiopathic Parkinson disease
• Stable dopaminergic medicine ≥ 2 weeks
• Able to walk 10 meters without aid
• Mini-Mental Status Examination ≥ 24 points
• No uncorrected visual or auditory disorders
• Education at least junior high school
• No other disease may affect balance

Критерии исключения

• Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
• History of brain surgery (e.g. deep brain stimulation)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Тайвань · 1 центр

• National Yang Ming Chiao Tung University — Taipei

Идентификаторы

NCT: NCT06588439 · NYCU113006AF2

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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