Strength Training and Resveratrol

Официальное название

Resveratrol-mediated Changes in Extracellular Vesicle microRNA Cargo as a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults

Обзор

The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.

Подробное описание

After screening and providing informed consent, participants (healthy older adults, age 60+, minimally active) will be familiarized with the procedures and undergo pre-testing. After pre-testing, participants will be assigned to supplement with resveratrol or placebo (double-blinded) daily while undergoing a strength training intervention. Strength training will be performed 3x/week for two 6-week blocks, and each visit will be supervised by a member of the study team. An additional week of testing will follow each of the two 6-week blocks.

Вмешательства

• Поведенческое Resistance training
  After pre-testing, participants will perform full-body strength training three times per week for two 6-week blocks. The acute program variables (sets, repetitions, training frequency) will follow a non-linear periodized, progressive design consisting of muti-joint and single-joint exercises. Exercise stress will be varied by using different exercises and loads. The two training blocks will be separated by a mid-intervention testing week, allowing for the study team to monitor participants' prog
• Пищевая добавка Resveratrol 500 mg oral once daily.
  Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.
• Пищевая добавка Placebo
  Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Первичные конечные точки

• Circulating extracellular vesicle microRNA profile [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Muscle torque [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Muscle fatigability [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Muscle strength [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Appendicular skeletal muscle mass index [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]

Вторичные конечные точки (6)

• Waist-to-hip ratio [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Vascular function [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Cognitive function [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Grip strength [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Lower body strength/endurance [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
• Gait speed [Срок оценки: During pre-, mid-, and post-testing (each separated by about 6 weeks)]

Критерии участия

Критерии включения

• Age 60+
• Minimally active (less than 1 hour of structured exercise/week other than walking)
• No resistance training for the previous 6 months
• Not currently taking resveratrol supplements
• Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period
• Body mass at least 110 lbs

Критерии исключения

• Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
• Cannabis or nicotine use
• Consume more than 7 alcohol-containing beverages per week

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Тройное слепое

Основная цель

Профилактика

Центры проведения

США · 1 центр

• Department of Kinesiology & Sport Management, Texas Tech University — Lubbock

Идентификаторы

NCT: NCT06585865 · YI-2024-02 · IRB 2024-587

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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