Cardiovascular Health & Early Stress

Обзор

Childhood adversity is highly prevalent, with 59% of the U.S. population reporting at least one adverse childhood experience (ACE). Substantial evidence links childhood adversity to cardiometabolic disease later in the life course, including heart disease, diabetes, and stroke, which are 3 of the top 10 causes of mortality in the United States. ACEs encompass many possible traumatic and distressing experiences, including abuse, neglect, or severe household dysfunctions. It is not surprising that the experience of those extreme events during the first decade of life has tremendous implications for the individual's psychological and physical health.

Подробное описание

Current knowledge supports that ACEs trigger emotional stress, anxiety, fear, and discomfort in the individual. Acute and intense mental stress leads to structural changes in the amygdala, prolonged activation of the hypothalamic-pituitary-adrenal axis, and hyperactivation of the sympathetic nervous system. Then, the body secretes hormones to activate the cardiovascular system to cope with stress with a rapid increase in arterial pressure and heart rate. If the trauma is severe and/or repeated, the resting state for heart rate and blood pressure are readjusted, resulting in these children living in a heightened physiological state of arousal, including higher heart and respiration rates. This status leads to endothelial dysfunction and atherothrombotic activation that can contribute to premature cardiovascular dysfunctions. Notably, there is evidence of a cumulative effect, or dose-response relationship, between the number of reported ACEs and the prevalence of health risk behaviors and chronic diseases. Thus, despite the prevalence of ACEs and the impact on health and society, the mechanisms underlying these dysfunctions are still poorly understood. The present study aims to understand the impact of different types of ACEs on cardiovascular health.

Вмешательства

• Другое Childhood stress
  Based on stress-related information, participants will be divided into those who were exposed to adversity during childhood and those who were not exposed.

Первичные конечные точки

• Vascular function [Срок оценки: Baseline]
• Cardiac Function [Срок оценки: Baseline]
• Cardiac MRI (CMR) [Срок оценки: Baseline]

Вторичные конечные точки (7)

• Spirometry [Срок оценки: Baseline]
• Lung Diffusing Capacity [Срок оценки: Baseline]
• Complete blood count [Срок оценки: Baseline]
• HbA1c [Срок оценки: Baseline]
• C-Reactive protein [Срок оценки: Baseline]
• Questionnaires [Срок оценки: Baseline]
• Arterial Stiffness [Срок оценки: Baseline]

Критерии участия

Критерии включения

Cohort 1

• Men and pre-menopausal women
• 18-30 years old

Cohort 2

• males and females
• 9-17 years old

Критерии исключения

Cohort 1

• Evidence of cardiovascular, pulmonary, renal, hepatic or cerebral diseases
• Evidence of pregnancy or currently nursing.
• Having a history of chronic pain
• Having a history of rheumatoid arthritis

Cohort 2

• Evidence of cardiovascular, pulmonary, renal, hepatic or cerebral diseases
• Evidence of pregnancy or currently nursing.
• Having a history of chronic pain
• Having a history of rheumatoid arthritis

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

США · 1 центр

• Virginia Commonwealth University — Richmond

Идентификаторы

NCT: NCT06557707 · HM20021768

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗