Идёт набор NCT06551311

The Effects of Eccentric Cycling Exercise Program in Chronic Kidney Disease Patients

Без фазы С лечением Chronic Kidney Disease

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: cycling training exercise.
Кому может быть актуально: Состояния в реестре: Chronic Kidney Disease. Базовые параметры: 55 лет — 85 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Тайвань
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

To Explore Efficacy and Load of Eccentric Cycling Training in Older CKD Patients with or Without Sarcopenia

Обзор

Progress in medical technology, enhancements in environmental cleanliness, and elevated living conditions have notably prolonged the mean life expectancy, resulting in a swift increase in the aging population. The prevalence of Chronic Kidney Disease (CKD) is more pronounced among the elderly in contrast to younger demographics. With the aging of the CKD population, the capacity to autonomously handle daily activities becomes a critical concern. This demographic frequently encounters concurrent health conditions, a decrease in self-care capabilities, general health decline, and diminished quality of life. Recent studies suggest that physical activity has the potential to enhance cardiovascular health, cardiopulmonary endurance, muscle strength, quality of life, uremic toxin management, and inflammation levels among individuals with CKD. Given that CKD patients often exhibit sedentary behavior and reduced exercise capacity, eccentric cycling exercises may be particularly well-suited for this demographic. Compared to concentric contractions, eccentric contractions subject the muscles to higher tension. Since muscle growth partially depends on the "stress exerted on muscle fibers"-meaning the greater the stress, the more stimulation the muscles receive-training focused on eccentric contractions could provide more stimulation and promote greater muscle growth. In recent studies, eccentric cycling has emerged as a feasible and promising aerobic exercise intervention. It can provide a safe and appropriate amount of exercise while relatively reducing joint pressure. This novel combined aerobic and anaerobic exercise method is particularly beneficial for individuals with weaker lower limb muscles, lower joint pressure tolerance, poor metabolic and cardiovascular function, and a tendency to fatigue.

Подробное описание

The previous study did not examine the impact of eccentric cycling exercise training on individuals with CKD. This study focuses on exploring the effects of eccentric cycling exercise on various aspects including body composition, functional capacity, flexibility, muscle strength, exercise capacity, pulmonary function, quality of life, and renal function in CKD patients. A comparison will be made between eccentric cycling exercise training, concentric cycling exercise training, and the usual care provided. The goal is to provide a clearer understanding of how eccentric cycling exercise can benefit individuals with CKD.

Вмешательства

Поведенческое cycling training exercise
Participants were randomly allocated to one of three groups: control (CTL), concentric cycling training (CON), or eccentric cycling training (ECC). CTL: Received standard health education guidance. CON and ECC: Participants in both the CON and ECC groups engaged in 24 exercise sessions, performed three times per week, lasting between 20 and 30 minutes. Both groups trained on a stationary bicycle, with the CON group performing concentric cycling and the ECC group performing eccentric cycling. T

Первичные конечные точки

Cardiopulmonary Exercise Testing (CPET) [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Pulmonary function test [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Maximum respiratory pressure (MIP/MEP) [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Six Minute Walk Test (6MWT) [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Lower limb strength-Knee Extension Strength Test [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]

Вторичные конечные точки (5)

Physical fitness-Body composition [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Physical fitness-Flexibility [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Physical fitness-muscle strength [Срок оценки: at Baseline, midterm test (at 4 weeks), post-test (at 8 weeks), and follow-up test (at 12 weeks)]
Quality of life indicators-SF-36 Questionnaire [Срок оценки: at Baseline and follow up test (at 12 weeks)]
Quality of life indicators- KDQOL Questionnaire [Срок оценки: at Baseline and follow up test (at 12 weeks)]

Критерии участия

This study will be conducted in collaboration with the Departments of Nephrology and Geriatric Medicine at National Cheng Kung University Hospital, Taiwan. Participants will be recruited as voluntary subjects from outpatient clinics. The attending physician will assess eligible patients. After the study's purpose and methodology are explained by the research staff and patients consent to participate, block randomization will be used to assign participants into one of three groups randomly. The allocation results will be securely stored by the principal investigator.

Критерии включения

(1) Clinical diagnosis of CKD
(2) eGFR <60 ml/min/1.73m\^2 or undergoing routine dialysis
(3) Must be able to communicate normally, understand and comply with instructions.
(4) Must be able to walk independently.