Neural Adaptations to Metronome-Paced Strength Training

Официальное название

Neural Adaptations to Metronome-Paced Strength Training: Insights From Neuroscience and Human Movement Variability

Обзор

The aim of the study is to investigate the effects of incorporating variability within Resistance Training (RT) methods on the neural adaptations along the corticospinal tract and on neuromuscular function. The literature suggests that RTis one of the most common modalities to enhance and restore muscle function and its practice results in adaptation in neural and morphological adaptations. It is also known that conditions such as ageing and injury have a negative impact on neural drive to the muscles with consequences at motor control level that are not addressed by traditional RT. Recent approaches such as metronome paced strength training have been used to cover this motor control dimension through a greater control and consciousness of movement. However, this methodology tends not to incorporate the inherent variability and complex, fractal-like fluctuations that characterize human movement. The investigators propose that incorporating variability through a fractal-like metronome approach will speed up the neural adaptations which will be useful in injury rehab.

Вмешательства

• Другое Fractal Paced
  The intervention consists in a metronome-paced strength training session performed 3 times per week (with 48h of rest between sessions), during 4 weeks. Each session consists in 4 sets of 15 repetitions at 65% of the one-repetition maximal (1RM) in single leg extension machine, synchronizing each repetition with fractal external cues presented by a visual metronome. The rest between sets will be set at 2 minutes of rest between sets.
• Другое Isochronous Paced
  The intervention consists in a metronome-paced strength training session performed 3 times per week (with 48h of rest between sessions), during 4 weeks. Each session consists in 4 sets of 15 repetitions at 65% of the one-repetition maximal (1RM) single in leg extension machine, synchronizing each repetition with isochronus external cues presented by a visual metronome. The rest between sets will be set at 2 minutes of rest between sets.
• Другое Self Paced
  The intervention consists in a metronome-paced strength training session performed 3 times per week (with 48h of rest between sessions), during 4 weeks. Each session consists in 4 sets of 15 repetitions at 65% of the one-repetition maximal (1RM) in single leg extension machine, at their own self pace (with no metronome). The rest between sets will be set at 2 minutes of rest between sets.

Первичные конечные точки

• Corticospinal Excitability (CSE) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Short-interval Intracortical Inhibition (SICI) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Corticospinal Silent Period (CSP) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Intracortical Facilitation (ICF) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Lumbar Evoked Potentials (LEP) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Maximal Compound Action Potentials (Mmax) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• StartReact Gain changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]

Вторичные конечные точки (6)

• Single leg extension 1RM changes after 4-weeks intervention (PRE to POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Maximal Voluntary Isometric Contraction (MVIC) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Sample Entropy (SampEn) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Coefficient ov variation (CV) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Motor Unit Action Potentials (MUAP) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]
• Firing Rate (FR) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups [Срок оценки: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)]

Критерии участия

Критерии включения

• aged between 18 and 40 years

Критерии исключения

• Neurologic conditions;
• Lower limb disabilities or disease;
• Not able to provide informed consent;
• Have an implanted device (e.g. pacemakers) or any metal in the body;
• Medication advised against the application of Transcranial Magnetic Stimulation;
• History/family history of seizures, brain lesions or head trauma, neurological or psychiatric diseases, epilepsy, migraine

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Фундаментальное исследование

Центры проведения

Португалия · 1 центр

• Egas Moniz School of Health & Science — Almada

Идентификаторы

NCT: NCT06532786 · METROTRAIN - 1403

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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