Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland)

Multiple Sclerosis (MS) is a chronic disease of the central nervous system that causes a range of neurological symptoms, such as cognitive issues, fatigue, vision problems, and muscle weakness. There are two main forms: relapsing-remitting MS (RRMS) with episodes of symptoms that improve on their own, and primary progressive MS (PPMS) with chronically worsening symptoms. Many RRMS patients eventually develop secondary progressive MS (SPMS), where disability worsens without remissions. What causes MS remains unknown, but it is thought to involve genetic and environmental factors. Diagnosis and monitoring typically involve patient history, neurologic examination in combination with magnetic resonance imaging (MRI), and other tests, but these methods are costly and time-consuming. Efforts are made to develop digital tools for continuous patients monitoring.

This study is part of the Clinnova programme, aiming to collect standardized and high-quality digital health data. Clinnova-MS is a prospective cohort study including patients with early MS or those transitioning to progressive MS. Up to 100 patients, recruited from the ongoing Swiss MS cohort study, are enrolled in Basel, Switzerland. An equivalent number of patients are enrolled in other Clinnova centers, reaching at least 800 patients in total. The study aims to provide a structured and standardized highly granular dataset, allowing for the phenotyping of patients with similar patterns and disease courses. It also facilitates transnational data linkage the analysis of complex and heterogeneous data from MS patients.

The primary objective of the study is to derive a set of biomarkers that will better characterize the clinical phenotype and progression of the disease, as well as the functional impairment of MS patients at different stages. These biomarkers will aid clinicians in making informed treatment decisions for patients with early MS or those transitioning to progressive MS.

• Expanded Disability Status Scale (EDSS) [Срок оценки: Baseline and once a year for up to 5 years]
• 9-Hole Peg Test (9-HPT) [Срок оценки: Baseline and once a year for up to 5 years]
• Timed 25-Foot Walk (T25FW) [Срок оценки: Baseline and once a year for up to 5 years]
• Stroop Test (Victoria Version) [Срок оценки: Baseline and once a year for up to 5 years]
• Symbol Digit Modalities Test (SDMT) [Срок оценки: Baseline and once a year for up to 5 years]
• Trail Making Test A&B (TMT A&B) [Срок оценки: Baseline and once a year for up to 5 years]
• Multiple Sclerosis Inventory of Cognition (MUSIC) [Срок оценки: Baseline and once a year for up to 5 years]
• Digit span backwards (DSB) [Срок оценки: Baseline and once a year for up to 5 years]
• Rey-Osterrieth Complex Figure Test (ROCF) [Срок оценки: Baseline and once a year for up to 5 years]
• Verbal Learn and Memory Test (VLMT) [Срок оценки: Baseline and once a year for up to 5 years]
• Near vision acuity test [Срок оценки: Baseline and once a year for up to 5 years]
• Contrast vision test (Pelli-Robson low-contrast chart) [Срок оценки: Baseline and once a year for up to 5 years]