Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)

Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea. Existing clinical studies show correlation between dose to the DVC and nausea, but they concern tumors of the airways and upper digestive tract, where there are many confounding factors.

A retrospective study was carried out a in the radiotherapy oncology department of Bordeaux University Hospital on 102 patients irradiated for a benign brain tumor. This study showed that DVC irradiation was significantly associated with the onset of nausea. However, this symptom alters the quality of life on a daily basis.

The objective of this prospective, multicenter, non-interventional study is to evaluate, using nausea validated questionnaires : Functional Living Index-Emesis (FLIE score), the correlation between DVC irradiation and nausea in benign brain tumors, at the end of radiotherapy, 1 month later and 3 months later. Fatigue associated with brain irradiation will also be studied with BFI (Brief Fatigue Inventory).

If there is an established link, a secondary dose constraint on this structure will be able to be proposed to reduce nausea in these radiotherapy indications.

• Nausea grading [Срок оценки: At inclusion, at day 35 of radiotherapy, at 1 and 3 months after completion of radiotherapy]
• Brief Fatigue Inventory (BFI) [Срок оценки: At inclusion, at day 35 of radiotherapy, at 1 and 3 months after completion of radiotherapy]
• Dosimetric parameters of the Dorsal Vagal Complex [Срок оценки: One day after completion of radiotherapy]
• Dosimetric parameters of the Braintem [Срок оценки: One day after completion of radiotherapy]