Characterization of Olfactory Perception in Post-Traumatic Stress Disorder

Обзор

The core symptoms of post-traumatic stress disorder (PTSD) include flash backs, intrusive pictures and thoughts related to the traumatic event, hyperalertness, avoidance of traumatic relevant environmental triggers and emotional dysregulation. Some studies suggest that PTSD is also associated with impaired olfactory perception, which seems quite intuitive regarding the close anatomical-functional connections between olfactory and emotional circuits. Furthermore, some studies reported that olfactory stimuli can trigger flashbacks in subjects with PTSD. However, up to know available data is scarce and heterogeneous concerning that topic. The goal of the study is to determine the olfactory phenotype of subjects with PTSD. More precisely, this project aims at filling the above mentioned gap by systematically assessing the olfactory perception of subjects with PTSD along five dimensions: olfactory identity, hedonic value, familiarity, desirability and edibility. As a secondary goal, the relative weight of olfaction compared to the other senses in the relived memories of subjects with PTSD will be assessed. The investigators here hypothesize a global impairment in olfactory processing (intensity, hedonicity, familiarity and edibility judgments) in PTSD subjects, compared with healthy subjects.

Вмешательства

• Поведенческое European Test of Olfactory Capabilities (ETOC)
  Investigators will collect the ETOC score in patient of both arms
• Поведенческое Standardized Hedonicity Test
  To smell 20 odorant solutions and for each odor and evaluate it along five dimensions: familiarity, hedonicity, edibility, desire to smell again, perceived intensity). Each dimension is assessed with a Likert scale (from 1 (not at all) to 9 (extremely))
• Поведенческое Questionnaires
  Patients with PTSD will have the following questionnaires : PTSD Checklist for Diagnostic and Statistical Manual (DSM)-V (PCL-5), Peri-trauma Dissociation Experience Questionnaire (PDEQ), Patient Health Questionnaire-9 (PHQ9), Snaith-Hamilton Pleasure Scale (SHAPS), Childhood Trauma Questionnaire (CTQ) and Apathy Evaluation Scale (AES)
• Поведенческое Odor / trauma association questionnaire
  Patients with PTSD will have Odor / trauma association questionnaire

Первичные конечные точки

• Standardized Hedonicity Test score [Срок оценки: at inclusion]

Вторичные конечные точки (3)

• Effects of potential moderators on odor judgement [Срок оценки: at inclusion]
• Evaluation of sensory impressions of memories evoked by certain odors. [Срок оценки: at inclusion]
• Evaluation of emotional valence of memories evoked by certain odors. [Срок оценки: at inclusion]

Критерии участия

Критерии включения

• Age between 18 to 50
• Subjects with PTSD

Критерии исключения

• Patients with a neurological history such as stroke, head trauma (e.g. exposure to explosions, sports injury…), neurodegenerative disease…
• Any psychiatric condition except PTSD and major depressive disorder
• Current or recent use of psychotropic drugs that may affect olfactory function.
• Any current or remitted addictive disorder.
• Pregnancy and breast-feeding women

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Случай-контроль

Центры проведения

Франция · 1 центр

• Auvergne-Rhône-Alpes Regional Center for Psychotrauma — Lyon

Идентификаторы

NCT: NCT06494306 · 69HCL24_0189

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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