Speech Motor Learning and Retention (Aim 2)

Официальное название

Sensorimotor Basis of Speech Motor Learning and Retention

Обзор

The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.

Подробное описание

The focus of this registration is Aim 2. Specific Aim 2 assesses the temporal order in which plasticity occurs in cortical motor and sensory brain areas during speech motor learning. Plasticity is assessed using measures of cortical excitability. Specifically, auditory, somatosensory and motor evoked potentials are elicited using single pulse TMS (motor), pure tone bursts (auditory), and mentalis nerve stimulation (somatosensory). Tests of cortical excitability are interleaved with trials involving speech motor adaptation. Cortical excitability is also measured using these same measures 24 hours after learning to assess retention.

The Speech Motor Learning and Retention Master Protocol is NCT06467292.

Вмешательства

• Поведенческое Adaptation
  Auditory adaptation in speech
• Поведенческое Adaptation baseline
  Auditory baseline in speech
• Устройство Motor evoked potentials
  motor evoked potentials will be obtained in each recording block
• Устройство Auditory evoked potentials
  auditory evoked potentials will be obtained in each recording block
• Устройство Somatosensory evoked potentials
  Somatosensry evoked potentials will be obtained in each recording block

Первичные конечные точки

• Speech motor learning [Срок оценки: Performance as measured at the end of learning (30 minute session)]
• Retention of learning [Срок оценки: 24 hours after learning (re-test lasts 30 minutes)]
• Motor evoked potentials (MEPs) [Срок оценки: Performance as measured at the end of learning (30 minute session)]
• Somatosensory evoked potentials (SEPs) [Срок оценки: Performance as measured at the end of learning (30 minute session)]
• Auditory evoked potentials (AEPs) [Срок оценки: Performance as measured at the end of learning (30 minute session)]

Критерии участия

Критерии включения

• Fluent English speakers
• Right-handed
• Normal hearing
• No speech disorder or reading disability

Критерии исключения

• Cardiac pacemaker
• Aneurysm clip
• Heart or Vascular clip
• Prosthetic valve
• Metal implants
• Metal in brain, skull, or spinal cord
• Implanted neurostimulator
• Medication infusion device
• Cochlear implant or tinnitus (ringing in ears)
• Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
• Psychoactive medications
• Pregnancy

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• Yale Child Study Center — New Haven

Идентификаторы

NCT: NCT06491823 · 2000037622_b · 1R01DC022097-01A1

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗