Mechanisms for Laser-Induced Rejuvenation
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Fractionated Laser Resurfacing.
- Кому может быть актуально
- Состояния в реестре: Skin Cancer. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- США
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Обзор
It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.
Вмешательства
- Устройство Fractionated Laser Resurfacing
A rejuvenating laser that makes tiny holes in the very superficial part of the skin.
Первичные конечные точки
- To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes. [Срок оценки: 2 weeks prior to skin removal and 1 week prior to skin removal]
- To test if possible cells transitioning from monocytes to fibroblasts are found in the top part of the dermis (papillary dermis). [Срок оценки: 2 weeks prior to skin removal and 1 week prior to skin removal]
Вторичные конечные точки (3)
- To define the number and types of cells populating the skin following fractionated laser resurfacing (FLR) wounding [Срок оценки: 2 weeks prior to skin removal and 1 week prior to skin removal]
- To define the locations of the number of cells populating in the skin following fractionated laser resurfacing (FLR) wounding [Срок оценки: 2 weeks prior to skin removal and 1 week prior to skin removal]
- To define the locations of the types of cells populating in the skin following fractionated laser resurfacing (FLR) wounding [Срок оценки: 2 weeks prior to skin removal and 1 week prior to skin removal]
Критерии участия
Критерии включения
- Adult males and females 18 and older
- Able to comprehend procedures and risks
- Planning to undergo abdominoplasty surgery
- Minimum amount of skin to be removed is 50 x 20cm
Критерии исключения
- Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
- Pregnant or nursing
- History of pathologically abnormal wound healing such as keloidal scars
- Existing tattoos on the abdomen that are so extensive that they could interfere with the study
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Распределение
- Не применимо
- Модель
- Одна группа
- Маскирование
- Открытое
- Основная цель
- Профилактика
Центры проведения
США · 1 центр
- Pharmacology Translational Unit — Fairborn
Идентификаторы
NCT: NCT06489301 · 2023-312