Study of Intra- and Interpersonal Multimodal Synchronizations in a Social Interaction in Individuals with a Diagnosis of Schizophrenia.

Официальное название

Study of Multimodal Intra- and Interpersonal Synchronizations in Social Interaction in Individuals with a Diagnosis of Schizophrenia.

Обзор

The aim of this study is to precisely identify deficits in intra- and interpersonal multimodal synchronizations during social interaction in individuals with schizophrenia (ISZ). During a social interaction, individuals use both visual and auditory channels to construct their discourse. The auditory channel encompasses the semantics and prosody of the speech, while the visual channel describes the entirety of non-verbal gestures (e.g., facial expressions, body movements). Prosody and non-verbal gestures are essential elements for the speaker. By accompanying speech, they contribute to the planning and conceptualization of the utterance and enhance its communicative power. For the listener, prosody and non-verbal gestures are also used to provide sensory feedback to the speaker. Several studies have shown the existence of intrapersonal and interpersonal synchronizations of prosody and non-verbal gestures during interaction. These synchronizations are associated with numerous social benefits (e.g., increased mutual appreciation and quality of interaction). However, certain mental disorders, such as schizophrenia, exhibit deficits in non-verbal behaviors that can impair these synchronizations and the associated social benefits. We hypothetized that interaction with individuals with a daignosis of schizophrenia will be associated with deficits in intra and interpersonal synchronization.

Подробное описание

This study includes a pre-inclusion interview followed by a visit to the university hospital (CHU) lasting about 2 hours (including a break). During the visit, the patient participates in an experimental protocol consisting of two parts. In the first part, the patient will be paired with an interaction partner, and the two participants will engage in four distinct conversational tasks, including getting to know each other, free discussions, structured dialogues, and emotional interactions. In the second part, the participants will answer several questionnaires and perform neuropsychological tests in collaboration with an experimenter

Вмешательства

• Поведенческое Social interaction
  Participants are required to speak to one another. Participants are given various topics of conversation.

Первичные конечные точки

• interpersonal synchronization [Срок оценки: 4x6 minutes]
• intrapersonal synchronization [Срок оценки: 4x6 minutes]

Вторичные конечные точки (2)

• correlation between primary outcomes and individuals with schizophrenia medications [Срок оценки: 4x6 minutes]
• correlation between synchronization and willingness to continue the interaction [Срок оценки: 4x6 minutes]

Критерии участия

Individuals with a diagnosis of schizophrenia :

Критерии включения

• diagnosis of schizophrenia according to the DSM-V
• being able to read, speak and understand french
• giving eclaired consent

Критерии исключения

• history of head trauma
• history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke)
• substance use
• pregnant women

Healthy controls :

Критерии включения

• being able to read, speak and understand french
• giving eclaired consent

Критерии исключения

• diagnosis of psychosis
• history of head trauma
• history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke)
• substance use
• pregnant women

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Фундаментальное исследование

Центры проведения

Франция · 1 центр

• Montpellier University Hospital — Montpellier

Идентификаторы

NCT: NCT06484387 · RECHMPL22_0408

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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