Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

Официальное название

The Effect of MRI-Guided Transcranial Direct Current Stimulation on Cognitive and Affective Symptoms in Persons With Parkinson's Disease and Controls

Обзор

The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantly improve the self-reported level of depression and apathy in patients with PD from pre-intervention to post-intervention compared to a sham control? 2) Can the use of mgTDCS significantly normalize the cortical eeg alpha asymmetry so commonly seen in depressed patients compared to sham mgTDCS? 3) Can the use of mgTDCS significantly improve scores on neuropsychological tests of working memory?

Подробное описание

This study seeks to expand the growing body of literature on the use of a particular type of low voltage electrical stimulation known as Transcranial Direct Current Stimulation (TDCS) to reduce the symptoms of Parkinson's Disease (PD). One common disorder that can result from, and/or be exacerbated by PD is Major Depressive Disorder. In particular, apathy has been noted as a common and detrimental component for those with PD. While many studies have been performed on PD patients using TDCS, the consensus in the literature is that results are widely variable.

Participants will:

* complete self-report measures and neuropsychological tests * undergo eeg recording pre and post intervention * participate in 15, 46 minute sessions (2 13 minute stimulation sessions with 20 minutes of rest between) of mgTDCS over the course of 4-5 weeks Researchers will compare active mgTDCS to Sham mgTDCS to see if active mgTDCS is more effective. A non Parkinson's group of depressed controls who are age-matched to the PD patients will serve to determine if treatment effects are specific to PD or generalize to depression more generally.

Вмешательства

• Устройство BIOPAC Stimsola
  Transcranial Electrical Stimulator
• Устройство BIOPAC Stimsola Sham (zero amps)
  Transcranial Electrical Stimulator set to 0 amps

Первичные конечные точки

• Beck Depression Inventory (BDI) Pre-post change score [Срок оценки: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.]
• Alpha band power pre-post change score [Срок оценки: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.]
• RBANS Working Memory [Срок оценки: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.]

Вторичные конечные точки (1)

• PDQ-39 [Срок оценки: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.]

Критерии участия

Критерии включения

• 19 to 65 years in age.
• Parkinson's Group must have a physician dx of Parkinson's Disease
• Must meet exhibit elevated levels of depression on the Beck Depression Inventory (scores of 20 or above).
• Must be willing and able to travel of the Psychology Department for EEG and tDCS sessions.
• Participants who have undergone surgery for Deep Brain Stimulation implantation may be enrolled if advised to and monitored by their physician.
• Read and understand spoken English.

Критерии исключения

• No history of or being treated for epilepsy or other seizure disorders.
• No history of penetrating head wounds or TBI greater than mild TBI.
• No history of atypical Parkinson's

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

США · 1 центр

• University of South Alabama — Mobile

Публикации

• Del Felice A, Castiglia L, Formaggio E, Cattelan M, Scarpa B, Manganotti P, Tenconi E, Masiero S. Personalized transcranial alternating current stimulation (tACS) and physical therapy to treat motor and cognitive symptoms in Parkinson's disease: A randomized cross-over trial. Neuroimage Clin. 2019;22:101768. doi: 10.1016/j.nicl.2019.101768. Epub 2019 Mar 18. PMID 30921609
• Brak IV, Filimonova E, Zakhariya O, Khasanov R, Stepanyan I. Transcranial Current Stimulation as a Tool of Neuromodulation of Cognitive Functions in Parkinson's Disease. Front Neurosci. 2022 Jul 12;16:781488. doi: 10.3389/fnins.2022.781488. eCollection 2022. PMID 35903808
• Broeder S, Vandendoorent B, Hermans P, Nackaerts E, Verheyden G, Meesen R, de Xivry JO, Nieuwboer A. Transcranial direct current stimulation enhances motor learning in Parkinson's disease: a randomized controlled trial. J Neurol. 2023 Jul;270(7):3442-3450. doi: 10.1007/s00415-023-11669-3. Epub 2023 Mar 23. PMID 36952012
• Broeder S, Nackaerts E, Heremans E, Vervoort G, Meesen R, Verheyden G, Nieuwboer A. Transcranial direct current stimulation in Parkinson's disease: Neurophysiological mechanisms and behavioral effects. Neurosci Biobehav Rev. 2015 Oct;57:105-17. doi: 10.1016/j.neubiorev.2015.08.010. Epub 2015 Aug 20. PMID 26297812
• de Oliveira PCA, de Araujo TAB, Machado DGDS, Rodrigues AC, Bikson M, Andrade SM, Okano AH, Simplicio H, Pegado R, Morya E. Transcranial Direct Current Stimulation on Parkinson's Disease: Systematic Review and Meta-Analysis. Front Neurol. 2022 Jan 10;12:794784. doi: 10.3389/fneur.2021.794784. eCollection 2021. PMID 35082749

Идентификаторы

NCT: NCT06467695 · 2128181

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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