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Идёт набор NCT06466980

Study of Ventilator Associated Event During Intensive Care After Resuscitated Cardiac Arrest.

— Наблюдательное Cardiac Arrest With Successful Resuscitation Mechanical Ventilation

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Ventilator associated event.
Кому может быть актуально
Состояния в реестре: Cardiac Arrest With Successful Resuscitation, Mechanical Ventilation. Базовые параметры: от 18 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Франция
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

The aim is to describe the incidence, characteristics, risk factors and outcome of complications acquired under mechanical ventilation (called ventilator-associated events) according to the new CDC criteria, in a population of patients admitted in intensive care unit after cardiac arrest.

Подробное описание

Cardiac arrest (CA) survivors are frequently admitted to intensive care units. Despite improvements in management techniques, the prognosis of these patients remains poor, with mortality exceeding 90% for out-of-hospital CA and around 80% for in-hospital CA, along with a high risk of severe neurological issue.

The management of these patients in intensive care requires the use of invasive mechanical ventilation. Complications occurring under mechanical ventilation have been the subject of many researches. Early bacterial pneumonia or ventilator-acquired pneumonia appears as the primary cause of respiratory worsening, and several studies have already focused on their incidence and prevention. However, studies on the benefits of antibiotic therapy or antibiotic prophylaxis for early pulmonary infections are of tricky analysis, particularly when they do not consider respiratory condition or mortality for their primary outcome measure.

A new definition of complications associated with mechanical ventilation (VAEs) has been established by the Centers for Disease Control and Prevention (CDC) since 2013. It offers a more relevant tool for monitoring the impact of preventive measures on morbidity and mortality, with a more objective definition that goes beyond just tracking ventilator-associated pneumonia.

Several studies have since analyzed the incidence and impact of VAEs on cohorts of intensive care patients, confirming the association between VAEs and morbidity and mortality. However, to our knowledge, none have targeted a population of cardiac arrest survivors.

Вмешательства

  • Другое Ventilator associated event
    Measure of incidence of Ventilator associated event

Первичные конечные точки

  • number [Срок оценки: at day 28]
Вторичные конечные точки (4)
  • Associated factors [Срок оценки: at day 28]
  • number of pneumonias [Срок оценки: at day 28]
  • time [Срок оценки: at day 28]
  • number of deaths [Срок оценки: at day 28]

Критерии участия

Критерии включения

  • Adult male or female
  • Non-pregnant female
  • Successfully resuscitated from cardiac arrest during primary care
  • Invasive mechanical ventilation initiated during resuscitation and continued for at least 4 days
  • No decision to limit life-sustaining therapies within 24 hours following admission to intensive care
  • No requirement of arteriovenous circulatory support during intensive care management

Критерии исключения

\- patients who opposed to the use of their data

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Франция · 1 центр
  • Centre Hospitalier Sud Francilien — Corbeil-Essonnes

Публикации

  • American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005 Feb 15;171(4):388-416. doi: 10.1164/rccm.200405-644ST. No abstract available. PMID 15699079
  • Perbet S, Mongardon N, Dumas F, Bruel C, Lemiale V, Mourvillier B, Carli P, Varenne O, Mira JP, Wolff M, Cariou A. Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1048-54. doi: 10.1164/rccm.201102-0331OC. PMID 21816940

Идентификаторы

NCT: NCT06466980 · 2024/0009

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗