Impact of Yoga on Cognitive Function

Официальное название

A Pilot and Feasibility Study of a Yoga Intervention in Heart Failure Patients With Mild Cognitive Impairment

Обзор

Mild cognitive impairment is highly prevalent in patients with heart failure and results in poor well-being and quality of life. While yoga has proven effective in promoting cognitive health in older adults through its gentle movements, controlled breathing, and meditation, its effects on patients with heart failure remain unknown. Therefore, this feasibility and pilot study plans to deliver a 12-week yoga intervention and test its effects on cognitive function in patients with heart failure and mild cognitive impairment.

Подробное описание

A prospective, 2-arm comparative feasibility design will be used. The investigators will enroll 24 patients with a confirmed heart failure diagnosis with mild cognitive impairment. Patients will be randomized equally into yoga intervention or control group. Patients in the yoga intervention group will receive a 60-minute yoga session twice per week for 12-week. Survey, cognitive function data, MRI scans, and blood samples will be collected at baseline and at 3 months (after completion of yoga intervention).

Вмешательства

• Поведенческое Yoga intervention
  Patients in the yoga group will receive a 60-minute session, twice per week over 12 weeks for a total of 24 sessions. Each yoga session consists of a warm-up, yoga postures standing or seated depending on the capability of the patient, and relaxation.
• Поведенческое Control condition
  Patients in the control group will receive care-as-usual from their healthcare providers and will be asked to avoid engaging in yoga during their 3 months in the study.

Первичные конечные точки

• Brain structure [Срок оценки: Change from 0-12 weeks, from baseline pre-intervention to 12 weeks post-intervention]
• Brain functional connectivity [Срок оценки: Change from 0-12 weeks, from baseline pre-intervention to 12 weeks post-intervention]
• Cognitive function [Срок оценки: Change from 0-12 weeks, from baseline pre-intervention to 12 weeks post-intervention]
• Serum brain-derived neurotrophic factor [Срок оценки: Change from 0-12 weeks, from baseline pre-intervention to 12 weeks post-intervention]

Критерии участия

Критерии включения

• Aged 55 years and older
• Confirmed heart failure diagnosis with mild cognitive impairment
• New York Heart Association functional class II-IV

Критерии исключения

• Co-existing neurological disorders, traumatic brain injury, psychiatric disorders, or terminal illnesses
• Have implanted defibrillator, left ventricular assist device placement or cardiac transplant
• Have any other implanted metals that interfere with the MRI magnetic field for patient safety
• Substance abuse
• Pregnant
• Unable to perform yoga due to physical limitations or severity of illness

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Профилактика

Центры проведения

США · 1 центр

• Auburn University — Auburn

Идентификаторы

NCT: NCT06434168 · AU-24-001

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗