Effects of CPRP on Patients Undergoing Lung Resection

Background: Elderly patients with compromised lung function or poor health conditions undergoing lung resection surgery face an increased risk of postoperative pulmonary complications. Pulmonary rehabilitation programs play a crucial role in enhancing recovery after surgery, having been shown to reduce postoperative pulmonary complications and enhance patients' pre- and post-operative exercise capacity, functional performance, and quality of life. However, due to the heterogeneity of interventions in pulmonary rehabilitation programs, the optimal timing, methods, or duration of exercise training for lung resection patients remain unclear. Additionally, there is a lack of comprehensive research on the changes and impacts of biomarkers in the blood of lung resection patients following intervention with pulmonary rehabilitation programs.

Objectives: This study aims to investigate the physiological and biological effects of a comprehensive pulmonary rehabilitation program in lung resection surgery patients with limited exercise capacity and impaired lung function.

Research Methods: This study adopts an open label, randomized, parallel design, intending to recruit 96 lung resection surgery participants divided into a control group receiving standard care and an experimental group receiving the comprehensive pulmonary rehabilitation programs. The intervention period spans 1-2 weeks pre-surgery, during hospitalization, and 3-6 weeks post-discharge. Participants will undergo four assessments at randomization (baseline, T0), one day pre-surgery (T1), the day of discharge post-surgery (T2), and at trial completion (T3). The primary endpoint is the six-minute walk test. Secondary endpoints include lung function, lung expansion volume, respiratory muscle strength, incidence of postoperative complications and pulmonary complications, chest tube duration, length of hospital stay, quality of life (EORTC QLQ-C30), and pain. Exploratory endpoints involve inflammation-related and immune-related biomarkers.

Expected Impact: This study will provide valuable insights into the physiological and biological effects of a comprehensive pulmonary rehabilitation programs for lung resection surgery patients. Results may contribute to improving patient outcomes and advancing academic understanding and clinical guidelines in this field.

• Pulmonary function test [Срок оценки: Baseline; one day pre-surgery; an average of post-surgery 2 weeks; through study completion, an average of 10 weeks]
• Respiratory muscle strength [Срок оценки: Baseline; one day pre-surgery; an average of post-surgery 2 weeks; through study completion, an average of 10 weeks]
• Length of hospital stay (LoS) [Срок оценки: an average of post-surgery 2 weeks]
• Duration of chest-tube insertion [Срок оценки: an average of post-surgery 2 weeks]
• Numerical Rating Scale (NRS) [Срок оценки: Baseline; one day pre-surgery; an average of post-surgery 2 weeks; through study completion, an average of 10 weeks]
• European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30, version 3, Chinese Mandarin (Taiwan)) [Срок оценки: Baseline; one day pre-surgery; an average of post-surgery 2 weeks; through study completion, an average of 10 weeks]
• Postoperative complications (POCs) and postoperative pulmonary complications (PPCs) [Срок оценки: an average of post-surgery 2 weeks]
• Lung expansion volume [Срок оценки: Baseline; one day pre-surgery; an average of post-surgery 2 weeks; through study completion, an average of 10 weeks]