Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Официальное название

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS

Обзор

The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.

Подробное описание

The aim of this prospective, multi-centered, double-blind, randomized, delayed-stimulation/ Sham-stimulation controlled 12-month study is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using the Infinity™ Deep Brain Stimulation (DBS) system as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) for adults who are experiencing a Major Depressive Episode (MDE) with inadequate response to 4 or more antidepressant treatments.

In a double-blind fashion, half the subjects will receive active DBS therapy, while half will receive sham stimulation. After the 12-month endpoint, all subjects will be unblinded to their treatment group, and subjects in the control arm will receive active DBS therapy.

Вмешательства

• Устройство Sham-stimulation
  Sham-stimulation
• Устройство Active-stimulation
  Active DBS

Первичные конечные точки

• Change in MADRS total score [Срок оценки: 12 months]
• CGI-I response rate [Срок оценки: 12 months]

Вторичные конечные точки (5)

• Percent time in MADRS response [Срок оценки: 12 Months]
• Percent time in MADRS partial response [Срок оценки: 12 Months]
• Percent time in CGI-I partial response [Срок оценки: 12 Months]
• MADRS Response Rate [Срок оценки: 12 Months]
• Q-LES-Q score change [Срок оценки: 12 Months]

Критерии участия

Критерии включения

• The patient must be diagnosed with non-psychotic unipolar Major Depressive Disorder.
• The patient must be in a major depressive episode for ≥12 months or have had at least 3 lifetime depressive episodes.
• The patient has tried and failed a minimum of four different types of antidepressant treatments as measured by a tool designed for this purpose.
• Depression medication and treatment regimen must be stable for a minimum of 4 weeks before the first baseline visit

Критерии исключения

• Pregnant or those who plan to become pregnant during study
• Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that could limit participation in the study or interfere with adherence to the study protocol.
• Current or lifetime history of psychotic features in any Major Depressive Episode.
• Has an intracranial Central Nervous System disease that impairs motor, sensory or cognitive function or that requires intermittent or chronic medication.
• Significant acute suicide risk.
• Diagnosis of Substance Use Disorder or Alcohol Use Disorder without sustained remission (12 months or longer).
• Current and ongoing use of neurostimulation treatment that may interfere with DBS therapy/system.
• Treatment with another investigational device or investigational drugs.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Четверное слепое

Основная цель

Лечение

Центры проведения

США · 24 центра

• University of Alabama at Birmingham - Dept. of Psychiatry — Birmingham
• USC University Hospital — Los Angeles
• UCLA Department of Psychiatry — Los Angeles
• University of California at Davis — Sacramento
• USF Health — Tampa
• Emory University Hospital — Atlanta
• Rush University Medical Center — Chicago
• Indiana University — Indianapolis
• … и ещё 16 центров

Идентификаторы

NCT: NCT06423430 · ABT-CIP-10494

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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