TIP Regimen Combined With Triplizumab Neoadjuvant Therapy for Locally Advanced Penile Cancer

Официальное название

A Single-center, Single-arm Clinical Study of TIP(Paclitaxel + Ifosfamide + Cisplatin) Regimen Combined With Triplizumab Neoadjuvant Therapy for Locally Advanced Penile Cancer

Обзор

Primary Objective: To evaluate the efficacy and safety of TIP (paclitaxel + ifosfamide + cisplatin) combined with Toripalimab as a neoadjuvant treatment in locally advanced penile cancer

Подробное описание

Penile cancer is a rare malignant tumor, which often occurs in the inner plate of the prepuce and glans. Squamous cell carcinoma is the most common pathological type. Lymph node metastasis is a crucial factor that leads to poor prognosis of penile cancer. The 5-year OS of penile cancer patients without lymph node metastasis is 90%. Still, it goes down sharply in patients with inguinal lymph node metastasis and pelvic lymph node metastasis, which is 50% and 0%, respectively. Using neoadjuvant chemotherapy to treat patients with locally advanced penile cancer (T4, any N stage, or any T stage, N3) may improve their prognosis. TIP (Paclitaxel + Ifosfamide + Cisplatin) regimen is the first-line neoadjuvant treatment recommended by NCCN guidelines. PD-1 is an immune checkpoint molecule on the surface of T cells. In recent years, immune checkpoint inhibitors targeting PD-1 have shown good efficacy in a variety of tumors. Some phase II / III clinical trials have shown that PD-1 inhibitors can improve the prognosis of patients with lung squamous cell carcinoma, head and neck squamous cell carcinoma, and cervical cancer. Previous studies have found that PD-L1 is highly expressed in 40% - 60% of penile cancer, suggesting that penile cancer patients may benefit from immunotherapy. The management of penile cancer with lymph node metastasis is difficult, especially for the N2-3 stage. This phase II study aims to explore an effective combination therapy for locally advanced penile cancer. 25 patients need to be enrolled.TIP \& toripalimab will be administered every 21 days until surgery, evidence of disease progression, or onset of unacceptable toxicity.

Вмешательства

• Препарат Paclitaxel + Ifosfamide + Cisplatin & Toripalimab
  Paclitaxel + Ifosfamide + Cisplatin \& Toripalimab

Первичные конечные точки

• ORR [Срок оценки: 6 weeks]

Вторичные конечные точки (4)

• pCR [Срок оценки: 12 weeks]
• EFS [Срок оценки: 2 months]
• OS [Срок оценки: 6 months]
• Adverse events [Срок оценки: 2 months]

Критерии участия

Критерии включения

• Squamous cell carcinoma confirmed by histology or cytology;
• Clinical Stage is Locally advanced penile cancer (T4, any N stage; or any T stage, N3);
• No prior chemotherapy for newly diagnosed or relapsed patients or the time from the last chemotherapy to relapse should be longer than 12 months;
• There is at least one measurable lesion according to the solid tumor efficacy evaluation standard RECIST1.1;
• the Eastern Cooperative Oncology Group (ECOG) scored 0-2;
• Blood marrow function: Hemoglobin(Hb) >/= 80g/L; White blood cell count >/= 3.0x10\^9/L; Neutrophil count >/= 1.5x10\^9/L; Platelet count >/ = 100x10\^9/L;
• Liver function: AST, ALT, ALP </= 2.5 ULN; Total bilirubin </= 1.5 ULN;
• Estimated survival >/= 12 months;
• No prior serious disease history of a systemic organ;
• The participant understands this study procedure and signs the informed consent.

Критерии исключения

• Peripheral neuropathy degree >/=2 (affecting patient's function);
• Previously received any other experimental drug treatment within 4 weeks before enrollment;
• Patients with other cancer at present, or have other malignant tumor histories within the past 5 years. Except for (1) Cured skin non-malignant melanoma; (2) Curable tumor, including low-risk prostate cancer (T1a, Gleason score<6, PSA<0.5ng/ml), superficial bladder cancer and so on; (3) Other solid tumors have received radical treatment, and no recurrence or metastasis has been found at least 5 years;
• Other serious or poorly controlled concomitant diseases, including but not limited to (1) Severe or acute attack disease history of cardiovascular, liver, respiratory, kidney, blood, endocrine or neuropsychiatric system within 6 months; (2) Active infection history and needed antibiotic treatment within 2 weeks before enrollment; (3) Congestive heart failure (grade III-IV); (4) Unstable angina pectoris or myocardial infarction history within 6 months

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• Sun Yat-sen University Cancer Center — Гуанчжоу

Идентификаторы

NCT: NCT06415318 · B2024-043-01

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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