The Impact of Smoking on the Prognosis of Elderly Surgical Patients
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: none intervention.
- Кому может быть актуально
- Состояния в реестре: Delirium, Postoperative. Базовые параметры: 60 лет — 80 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Официальное название
The Impact of Smoking on Postoperative Delirium and Recovery Quality in Elderly Surgical Patients
Обзор
Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative cognitive dysfunction and even mortality. However, the underlying mechanisms of its onset are not yet fully understood. Evidence suggests that smoking can lead to gut microbiota dysbiosis and metabolic dysfunction, and the gut microbiota and its metabolites play a crucial role in cognitive function through the gut-brain axis. Yet, no studies have reported whether smoking could affect the occurrence of postoperative delirium and the quality of postoperative recovery through the gut microbiota. This study aims to observe the incidence of postoperative delirium and the postoperative recovery quality scores between smokers and non-smokers.
Подробное описание
After obtaining approval from the ethics committee, patients are recruited, informed of the trial process and potential risks, and their informed consent is obtained and signed. According to the WHO definition, patients are classified into smokers (defined as those who smoke more than one cigarette per day continuously or cumulatively for six months; more than four times a week but averaging less than one cigarette per day) and non-smokers (never smoked). Fecal and blood samples are collected from both groups of patients preoperatively, and perioperative data is gathered. Postoperatively, an uninformed observer assesses the patients for delirium and recovery quality.
Вмешательства
- Другое none intervention
No interventions are administered to either group of patients.
Первичные конечные точки
- Postoperative delirium [Срок оценки: Within 3 days post-surgery]
- Quality of recovery in the first postoperative day [Срок оценки: Up to 24 hours after surgery.]
Критерии участия
Критерии включения
- Age >60 years;
- American Society of Anesthesiologists (ASA) preoperative anesthesia classification ASA Grades I and II;
- Undergoing elective surgery;
- Patients and their families are able to understand and complete various scoring scales and voluntarily sign informed consent.
Критерии исключения
- Mini-Mental State Examination (MMSE) score <23;
- Preoperative biochemical tests indicate renal dysfunction or active liver disease;
- History of definite neurological or psychiatric disorders or history of taking corresponding medications before surgery;
- History of alcohol abuse or drug dependency;
- Taking antidepressant medications;
- American Society of Anesthesiologists (ASA) preoperative anesthesia classification > Grade II.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Китай · 1 центр
- Affiliated hospital of Nantong University — Nantong
Идентификаторы
NCT: NCT06392308 · 2023-K213-01