Идёт набор NCT06362122

Anatomo-clinico-biological Profiles in Severe Nasal Polyps

Без фазы С лечением NASAL POLYPS

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: identification anatomo-clinico-biological profiles.
Кому может быть актуально: Состояния в реестре: NASAL POLYPS. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Nasal sinus polyposis is a chronic inflammatory pathology of the nasal cavity and sinus cavities that causes bilateral and multifocal polyp development and has a prevalence of 2 to 4% in the general population. Therapeutic management consists of first-line medical treatment for anti-inflammatory purposes. Local corticosteroid therapy, using nasal sprays, is the background treatment. Surgical management is offered to patients in case of failure of medical treatment. Although effective, surgery does not protect patients from recurrence of symptoms related to regrowth of polyps. Recently, biologics have appeared, which despite its effectiveness, about 20% of patients have a partial or no response to these treatments. There is currently no possibility of determining the probability of response to treatments in patients. It is therefore essential to determine an anatomo-clinico-biological correlation associating the anatomopathological profile, the clinical characteristics and the cytokine signature in order to best guide the patient's management, including the initiation of biotherapy. Indeed, patients, according to their clinical, biological characteristics and the cytokine signature of their polyps will react differently to different treatments, including surgery and biotherapy. This correlation will serve as a predictor of treatment response.

Вмешательства

Другое identification anatomo-clinico-biological profiles
to determine an anatomo-clinico-biological correlation associating the anatomopathological profile, the clinical characteristics and the cytokine signature

Первичные конечные точки

Identify anatomical profiles present in nasal sinus polyposis resistant to medical treatment. [Срок оценки: 1 day]
Evaluation of symptoms related to nasal sinus polyposis by visual analogue scale [Срок оценки: 1 day]
Evaluation to quality of life by Sino-Nasal Outcome Test [Срок оценки: 1 day]
Identify biological profiles for patients with nasal sinus polyposis [Срок оценки: 1 day]
Evaluation to cytokine concentration in serum for patients with nasal sinus polyposis [Срок оценки: 1 day]

Критерии участия

Критерии включения

Patient ≥ 18 year-old
Patient with nasal sinus polyposis resistant to medical treatment and requiring surgical treatment with ethmoidectomy type is considered for the first time
Having signed the consent form
Having an health insurance