Braining - Evaluation of Acute Effects of Physical Exercise

"Braining" is a clinical invention that helps patients in psychiatry to start and execute physical exercise (PE) regularly in psychiatric care. The core components are basic moderate to vigorous aerobic group training sessions and motivational work led by the psychiatric staff. Braining is used as add-on treatment to regular psychiatric care and is included in the patient care plan.

In the present study, the focus is on the acute effects of a booster session of one to three Braining classes on psychiatric symptoms and biomolecular markers as well as impact on motivational factors.

Participants are recruited from the final cohort (N = 51) of the previous retrospective study, (Physical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety).This final cohort will be contacted to give written consent to partake in the booster session. The Braining classes each have a duration of 30 minutes and are scheduled over the course of a week.

Descriptive data on participating patients will be collected before the booster week. This will include age, gender, diagnoses, employment status. In conjunction with this, basic psychiatric and somatic examinations will be conducted.

During each Braining class, participants' activity level will be measured with a heart rate monitor to ascertain achieving moderate to vigorous intensity. Directly before and after each class, current anxiety level will be measured on a Visual Analogue Scale 0-100.

Within 30 minutes before and after one Braining class, venous blood samples (50 ml) will be taken for biomolecular markers. Blood samples include 1) inflammation markers such as high-sensitivity C-reactive protein hsCRP, 2) Brain-derived neurotrophic factor BDNF, 3) telomerase activity and 4) epigenetic markers.

Before and after the booster week, self-assessments scales for anxiety and depressive symptoms will be administered. Qualitative data on participants' experience as well as motivational factors will be collected.

• Beck Anxiety Inventory BAI [Срок оценки: Pre-intervention to post-intervention, timeframe 1 week]
• Montgomery-Åsberg Depression Rating Scale MADRS [Срок оценки: Pre-intervention to post-intervention, timeframe 1 week]
• High sensitivity C-reactive protein hsCRP [Срок оценки: Pre- to post-exercise class, timeframe 2 hours]
• Brain-derived neurotrophic factor BDNF [Срок оценки: Pre- to post-exercise class, timeframe 2 hours]
• Telomerase activity [Срок оценки: Pre- to post-exercise class, timeframe 2 hours]
• Motivational factors of continued exercise [Срок оценки: Pre-intervention to post-intervention, timeframe 1 week]