Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene

Официальное название

A Prospective, Open-label, Phase 1b, Single-arm, Safety Study of an Intravitreal Application of a Recombinant Adeno-associated Virus Vector Expressing CNGA1 (AAV2.NN-CNGA1) in Patients With Retinitis Pigmentosa Due to CNGA1 Mutations

Обзор

The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa. The main questions the study aims to answer are: * What is the best tolerated dose and are there any side effects, in particular any inflammatory reactions post drug administration? * Are there any early signs of efficacy on visual function? Participants will be administered a single intravitreal dose of VG901 into the most affected eye through a syringe and followed up for a year to monitor safety and efficacy. There will be two cohorts of participants in this study. Study Cohort 1 will receive the low dose and Study Cohort 2 will receive the high dose as specified in the Protocol.

Вмешательства

• Препарат VG901
  Administered as specified in the treatment arm. Study Cohort 1 - Low dose; Study Cohort 2 - High dose Other Names: Gene Therapy (AAV2.NN-CNGA1)

Первичные конечные точки

• Adverse Events (AEs) and Serious Adverse Events (SAEs) [Срок оценки: Baseline to Month 12]

Вторичные конечные точки (12)

• Physical Examination [Срок оценки: Screening to Month 12]
• Pulse rate [Срок оценки: Screening to Month 12]
• Blood pressure [Срок оценки: Screening to Month 12]
• Body temperature [Срок оценки: Screening to Month 12]
• Respiratory rate [Срок оценки: Screening to Month 12]
• Slit lamp examination [Срок оценки: Screening to Month 12]
• Fundus biomicroscopy [Срок оценки: Screening to Month 12]
• Optical coherence tomography (OCT) [Срок оценки: Screening to Month 12]
• Fundus autofluorescence [Срок оценки: Screening to Month 12]
• Tonometry [Срок оценки: Screening to Month 12]
• Adeno-associated virus (AAV) spread [Срок оценки: From Baseline until two consecutive samples test negative]
• Immunopathology [Срок оценки: Baseline to Month 12]

Критерии участия

Критерии включения

To be eligible for study entry, subjects must satisfy all the following criteria:

• Able to understand and willing to consent to study participation by a written informed consent
• Male or female ≥ 18 years of age
• Clinical diagnosis of RP
• Confirmed pathogenic, biallelic variants in the CNGA1 gene
• Ellipsoid zone (EZ) length of the fovea of ≥ 3000 μm in the study eye

Критерии исключения

Subjects will be excluded from the study if one or more of the following statements are applicable to either eye:

• Additional interfering ocular conditions which would impact study results (e.g., ocular opacity and advanced cataract, uveitis, amblyopia)
• History or presence of glaucoma
• Ocular surgery, intravitreal or subretinal implantation of a medical device (within 6 months of screening)
• Mutations known to cause inherited retinal disease other than biallelic variants in the CNGA1 gene
• History of ocular infection with herpes simplex virus
• History of ocular malignancies
• History of disorders of the internal retina (e.g., retinal detachment)
• Patients with uncontrolled diabetes (HbA1c > 7%)
• Any other retinopathy due to other diseases - including, but not limited to arterial hypertension, previous vascular retinal occlusion, trauma or acquired inflammatory diseases, contraindication to pharmacological mydriasis (e.g., history of angle block glaucoma), diabetes (diabetic retinopathy including macular oedema)
• Absence of visual function on the contralateral eye
• Any damage to the optic nerve
• Individuals performing any other therapy for RP within 3 months before the study, such as - but not limited to - transcorneal electrostimulation
• Systemic conditions (e.g., autoimmune disorders) which may affect study participation or outcome measures
• History of immunodeficiency or other medical conditions which may increase the risk of VG901 administration
• Systemic illness (e.g., hepatitis or human immunodeficiency virus \[HIV\] infection) or medically relevant abnormal laboratory values (3 x upper limit of normal \[ULN\]) in blood analysis including renal and hepatic function
• Current, or recent, participation in other study/ or administration of investigational biologic agent within 3 months of Screening; Use of any investigational agent, or systemic corticosteroids, or other immunosuppressive drug(s) within 3 months before Screening
• History of allergy or sensitivity to any compound used in the study
• Contraindications to systemic immunosuppression
• Subjects with increased risk of bleeding (i.e., use of anticoagulants or anti-platelet agents within 7 days before VG901 administration and subjects with international normalized ratio > 2 or Quick < 50% or partial thromboplastin time > 50 seconds, thrombocytopenia, as well as any other known coagulopathy)
• Subject/partner of childbearing potential unwilling to use adequate contraception for the period between Screening and 30 days after treatment, defined as the period from Screening until 30 days after treatment (defined as administration of therapeutic to the eye)
• For females of childbearing potential, a positive pregnancy test at Screening or Baseline
• Females who are breastfeeding
• Previous receipt of any AAV gene therapy product
• Any condition which leads the investigator to believe that subject cannot comply with the protocol requirements or that may place the subject at an unacceptable risk from participating

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Последовательный дизайн

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Германия · 1 центр

• Center for Ophthalmology, University of Tuebingen — Tübingen

Идентификаторы

NCT: NCT06291935 · VG901-2021 A · EU CT: 2023-504383-42-00

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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