Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-COVID-19 Syndrome

Официальное название

Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-Covid-19 Syndrome

Обзор

The objective of the study is to compare the acute cardiorespiratory and perceptual responses to a physical exercise session in those infected by Covid-19 with and without persistent symptoms.

Подробное описание

The study will be a crossover carried out in two groups (with and without persistent symptoms of Covid-19). Participants in both groups will undergo a control session and an exercise session and cardiorespiratory and perceptual responses will be obtained before, during and after the sessions. In the exercise session, participants will perform aerobic exercises, strength exercises and muscle stretching, while in the control session participants will remain seated. Blood pressure, heart rate, cardiac autonomic modulation, peripheral oxygen saturation, vascular function and perception of affect will be obtained.

Вмешательства

• Поведенческое Exercise session
  Session will included aerobic, resistance and flexibility exercises and will last approximately 45 minutes. The session will begin with aerobic exercises (5 min jumping jacks and 5 min stationary walking). Then, nine strength exercises will be performed for the main muscle groups (3 times of 12 to 15 repetitions, with a 1-minute rest interval) and finally stretching for the main muscle groups
• Поведенческое Control session
  Remain seated for 60 min

Первичные конечные точки

• Change in Blood pressure [Срок оценки: Before and 30 and 50 minutes after the end of the exercise and control interventions]
• Change in Heart rate variability [Срок оценки: Before and 30 and 50 minutes after the end of the exercise and control interventions]
• Change in flow mediated dilation [Срок оценки: Before and 30 minutes after the end of the exercise and control interventions]
• Change in peak exhalation flow [Срок оценки: Before and 5 minutes after the end of the exercise and control interventions]
• Change in oxygen saturation [Срок оценки: Before, during and 5 minutes after the end of the exercise and control interventions]

Вторичные конечные точки (2)

• Change in heart rate [Срок оценки: Before and continuously during exercise and control interventions]
• Change in affective response [Срок оценки: Before and every 5 minutes during exercise and control interventions]

Критерии участия

Критерии включения

Post-Covid Syndrome group:

• have had a positive RT-PCR test for Covid-19;
• present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
• have the cognitive and physical capacity to perform the exercises; It is
• low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Healthy group:

• not present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
• have the cognitive and physical capacity to perform the exercises; It is
• low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Бразилия · 1 центр

• Universidade Nove de Julho — São Paulo

Идентификаторы

NCT: NCT06248151 · Acute_Covid · 0057/2022

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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