Идёт набор NCT06202976

Mapping Epileptic Networks Using Multimodal Imaging

— Наблюдательное Epilepsy in Children

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Secondary data collection.
Кому может быть актуально: Состояния в реестре: Epilepsy in Children. Базовые параметры: до 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations. To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI). It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery. The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.

Вмешательства

Другое Secondary data collection
clinical data

Первичные конечные точки

Determine whether, in children with lesional focal epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG can accurately identify the epileptogenic zone to be defined by SEEG, today's gold standard. [Срок оценки: 15 years]

Вторичные конечные точки (7)

Study the pathophysiology of resistant lesional epilepsies [Срок оценки: 15 years]
Correlate cortical perfusion change on SL-ASMRI and BOLD signal abnormalities on resting-state fMRI [Срок оценки: 15 years]
Compare cortical perfusion abnormalities and resting-state fMRI based on EEG data in MRI. [Срок оценки: 15 years]
Correlate BOLD-MRI perfusion abnormalities with anatomical (DTI (tractography)) and functional (resting-state fMRI) brain connectivity abnormalities. [Срок оценки: 15 years]
Compare ASL-MRI and resting-state fMRI data coupled with EEG to the results of deep electrodes (intracranial EEG - SEEG), which are today's gold standard. [Срок оценки: 15 years]
Evaluate whether these data will eventually make it possible to reduce the frequency of intracranial EEG explorations (stereo EEG, subdural grids), with a view to replacing invasive deep electrodes in the future with multimodal MRI coupled to EEG in MRI. [Срок оценки: 15 years]
Improving understanding of the pathophysiology of rare non-lesional epilepsies [Срок оценки: 15 years]

Критерии участия

Критерии включения

Be under 18 years of age on the day of inclusion.
Present with one of the following forms of epilepsy:

refractory focal lesional epilepsy
rare non-lesional epilepsy
Present abnormalities (spikes) on the intercritical EEG
Have been selected by the "Epilepsy" multidisciplinary staff.
In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup.
Be affiliated to a health insurance scheme.