Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

Обзор

This research study is a randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of participants undergoing chemotherapy with either early-stage or metastatic colorectal cancer. The names of the study groups involved in this study are: * Exercise * Waitlist Control

Подробное описание

This research study is a single-center, two-armed, randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of participants undergoing chemotherapy with either early-stage or metastatic colorectal cancer. Participants will be randomly assigned to one of two groups: Group A: Exercise group (EXE) vs. Group B: Waitlist control group (WC). Randomization means that a participant will be placed into one of the study groups by chance.

The research study procedures include screening for eligibility, blood tests, stool samples, and survey questionnaires.

Participation in this research study will last up to 6 months.

It is expected that about 84 people will take part in this research study.

The American Cancer Society is providing funding for this research study.

Вмешательства

• Поведенческое Exercise Program
  A 12 week, home-based, virtually supervised, aerobic and resistance exercise training program comprised of 36 sessions. Participants will be provided with a home stationary bike, resistance bands, and Fitbit. Virtually supervised sessions will be accessible via Zoom platform. For participants who do not have a device, a Wi-Fi-enabled tablet will also be provided.

Первичные конечные точки

• Gut Microbiome Genomes [Срок оценки: Baseline (Week 1) and Post-intervention (Week 13)]

Вторичные конечные точки (1)

• Change in Chemotherapy Toxicity [Срок оценки: 12 weeks]

Критерии участия

Критерии включения

• Patient diagnosed with early-stage or metastatic colon or rectal cancer
• Age at diagnosis 18-50 years; due to the specificity of the study question those outside the age bracket will not be included
• No plans for major surgical intervention at the time of recruitment for a minimum of 12 weeks (i.e. study period; placement of port a cath is allowed)
• No plans for radiation therapy at the time of recruitment for a minimum of 12 weeks
• On or planning chemotherapy
• Participate in less than or equal to 90 minutes of moderate-to-vigorous exercise per week
• Medical clearance to perform exercise intervention and testing by their treating oncologist
• No uncontrolled medical conditions that could be exacerbated with exercise
• Ability to communicate and complete written forms in English
• Ability to understand and the willingness to sign informed consent prior to any study-related procedures
• Willing to travel to DFCI for necessary data collection

Критерии исключения

• Participate in more than 90 minutes of moderate-to-vigorous aerobic exercise per week over the past month. This study targets insufficiently active persons to assess the effect of the described exercise intervention, where additional exercise done regularly will contaminate the intervention effects.
• Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Patients with unstable comorbidities may develop unexpected adverse events from exercise. For the purpose of patients' safety, as well as because this study involves remote, home-based exercise where close supervision is not possible, patients with unstable medical conditions are excluded.
• Patients actively on a weigh loss diet and/or actively taking weight loss drugs. This could effect gut microbiome.
• Patient with other active malignancies (excluding basal cell carcinoma).
• Subjects who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Поддерживающая терапия

Центры проведения

США · 1 центр

• Dana Farber Cancer Institute — Boston

Идентификаторы

NCT: NCT06202183 · 23-341

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗