Идёт набор NCT06187012

Hypertension Explored in Long-term Postpartum Follow-up in Later Life

— Наблюдательное Hypertension Cardiovascular Diseases Cerebrovascular Disorders Vascular Diseases

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Hypertensive pregnancy.
Кому может быть актуально: Состояния в реестре: Hypertension, Cardiovascular Diseases, Cerebrovascular Disorders, Vascular Diseases. Базовые параметры: 30 лет — 70 лет · Женщины.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Великобритания
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Hypertension Explored in Long-term Postpartum Follow-up in Later Life (HELPFUL)

Обзор

The purpose of this study is to understand more about why women who have had hypertensive pregnancies may be at increased risk of high blood pressure and why these women are often at increased risk of heart and blood vessel disease later in life.

Подробное описание

Women who experience high blood pressure during pregnancy are at increased risk of developing cardiac and vascular diseases later in life. They show changes in their heart, brain, and blood vessels long before they develop high blood pressure. The investigators therefore think that these changes develop slowly over the course of the life of the woman and establish their risk of later disease.

Through better understanding of the pattern of changes across multiple parts of the body over extended periods of time, the investigators aim to identify how advanced the underlying disease is for an individual and how the disease is likely to develop over the next few years. By comparing the rate of change across different parts of the body, the investigators can examine how one area affects another.

Data including images of the heart, brain and blood vessels will be acquired in women 10 to 25 years after their pregnancy. The initial analysis will focus on assessing differences between women who have had a normotensive pregnancy and those who have had a hypertensive pregnancy, both at a single timepoint and in changes within individuals over time.

This dataset will then be used in conjunction with previously acquired data in women who have experienced a hypertensive pregnancy to find out how patterns emerge across the whole body. The investigators will subsequently combine information from different measures at the same time and use the machine learning models to learn the patterns of change that occur as a person progresses from a healthy to a diseased state.

This will allow the researchers to identify patterns of hypertensive disease development and it may open doors to better interventions and therapies tailored towards individuals.

Вмешательства

Другое Hypertensive pregnancy
Participants will attend one visit lasting approximately 3-4 hours on a single day or split over multiple visits to complete all measures. Participants will first be asked to provide written informed consent for the study. Participants' anthropometric measures (waist-to-hip ratio, height and weight, hip and waist circumference and left arm circumference and resting blood pressures will then be taken. After this, the participants will undergo cardiopulmonary exercise testing, followed by magnetic

Первичные конечные точки

Cardiac right ventricular mass [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy. Index pregnancy is defined as the pregnancy which we first collected data from.]

Вторичные конечные точки (12)

Cardiac left ventricular mass [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac right ventricular end-diastolic volume [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac right ventricular stroke volume. [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac left-ventricular end-diastolic volume. [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac left ventricular stroke volume [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac right ventricular systolic function [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac right ventricular ejection fraction [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac left ventricular systolic function [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac left ventricular ejection fraction [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac right ventricular diastolic function [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac left ventricular diastolic function [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]
Cardiac left ventricular diastolic function [Срок оценки: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy]

Критерии участия

Критерии включения

Inclusion Criteria

Participant is willing and able to give informed consent for participation in the study
Female who had a pregnancy 10 to 25 years prior
Able (in the investigator's opinion) and willing to comply with all study requirements.
Adequate understanding of verbal and written English

Критерии исключения

The participant may not enter the study if ANY of the following apply:

Over 10 weeks pregnant during the course of the study
Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status
Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study

For exclusion of MRI component only: