PET Imaging of 68Ga-NOTA-H006 in Malignancy
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: 68Ga-NOTA-H006 is injected intravenously with a dose of 1.8 MBq[0.05MCi]/kg..
- Кому может быть актуально
- Состояния в реестре: Tumor, Solid. Базовые параметры: 18 лет — 65 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
A Study to Evaluate 5T4 Expression in Malignant Tumors Using 68Ga-NOTA-H006
Обзор
5T4, also known as trophoblast glycoprotein, is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult. The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian, gastric and colorectal cancers. Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages. Previously, investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity. Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models. Thus, the aims of current study are to evaluate the distribution and dosimetry of this novel tracer, and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors.
Вмешательства
- Препарат 68Ga-NOTA-H006 is injected intravenously with a dose of 1.8 MBq[0.05MCi]/kg.
68Ga-NOTA-H006：PET imaging； 18F-FDG：PET imaging
Первичные конечные точки
- Establishment and optimization of imaging method for 68Ga-NOTA-H006 PET [Срок оценки: 90mins from time of injection]
Критерии участия
Критерии включения
- Pancreatic cancer clinical trial study subjects must meet all of the following criteria:
- Age between 18 and 65 years old.
- Pancreatic occupancy is found on imaging and combined with clinical judgment as a patient with pancreatic cancer.
- Written informed consent signed by the subject or his/her legal guardian or caregiver.
- Willingness and ability to cooperate with all programs of the study.
Lung cancer clinical trial study subjects must meet all of the following criteria:
- Be between the ages of 18 and 65 years old.
- Patients with CT findings of suspicious space on the lungs with a diameter of more than 1cm who have not undergone surgery.
- Written informed consent must be signed by the subject or his/her legal guardian or caregiver.
- Willingness and ability to cooperate with all programs of the study.
Bowel cancer clinical trial study subjects must meet all of the following criteria:
- Be between the ages of 18 and 65.
- Have a clear histologic or pathologic diagnosis of colorectal cancer.
- Written informed consent signed by the subject or legal guardian or caregiver.
- Willingness and ability to cooperate with all programs of this study.
Критерии исключения
- Severe hepatic or renal insufficiency;
- Targeted therapy prior to radiotherapy or PET/CT scan. 5T4 expression in existing lesions assessed by immunohistochemistry using antibody clones.
- History of serious surgery in the last month.
- Those who have participated in other clinical trials during the same period.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Распределение
- Не применимо
- Модель
- Одна группа
- Маскирование
- Открытое
- Основная цель
- Диагностика
Центры проведения
Китай · 1 центр
- Huashan Hospital — Шанхай
Идентификаторы
NCT: NCT06162988 · KY2023-777