Intramuscular Temperature on the Echo-textural Characteristics

Официальное название

Influence of Intramuscular Temperature on the Textural Characteristics of the B-mode Ultrasound Image.

Обзор

Echointensity and echotexture have been used as a physiological marker for changes in skeletal muscle quality and structure caused by physical training, low activity, ageing and some neuromuscular disorders. However, there are some influencing factors on muscle echo-intensity and echotexture, such as temperature, which may not be taken into account when performing an ultrasound assessment and may alter the results. This study aims to investigate the effects of muscle temperature on echointensity and other 2nd order echotextures variables such as homogeneity, contrast, correlation and entropy of muscle tissue, in order to gain a better understanding of this correlation and minimise its influence, which would allow greater precision in the use of muscle ultrasound as a diagnostic tool. The methodology of this study includes firstly the acquisition of ultrasound images of the vastus lateralis muscle. This acquisition will be performed during the continuous recording of muscle temperature, carried out during a passive cooling process after 20 min of heating using microwave equipment. In addition, to standardise the results, a correction factor will be calculated to compensate for the influence of subcutaneous adipose tissue thickness on echogenicity and echotexture.

Вмешательства

• Устройство Muscle warm-up
  Passive heating of the vastus lateralis of the right quadriceps will be performed using a microwave device. The device will be set at a power of 150 W and a distance of 10-15 cm from the skin surface for 20 minutes with the purpose of increasing local muscle temperature to 40 ºC.

Первичные конечные точки

• Muscle echointensity (0-255 a.u.). [Срок оценки: During intervention]
• Muscle echovariance (0-255 a.u.). [Срок оценки: During intervention]
• Muscle energy or second angular momentum. [Срок оценки: During intervention]
• Muscle homogeneity. [Срок оценки: During intervention]
• Contrast. [Срок оценки: During intervention]
• Textural Correlation. [Срок оценки: During intervention]
• Entropy. [Срок оценки: During intervention]
• Echointensity correction factor for adipose thickness [Срок оценки: Pre-intervention]
• Muscle temperature (ºC). [Срок оценки: Pre-intervention and during intervention]

Вторичные конечные точки (4)

• Age (years) [Срок оценки: Pre-intervention]
• Sex (female or male) [Срок оценки: Pre-intervention]
• Dominance [Срок оценки: Pre-intervention]
• Body mass index [Срок оценки: Pre-intervention]

Критерии участия

Критерии включения

• Acceptance of participation in the study.
• Healthy subjects.
• Subjects between the ages of 18 and 65.

Критерии исключения

• Have known neurological, cardiovascular, metabolic or orthopedic conditions that prevent them from participating in the study.
• Present metal implants in the heating area.
• Wear a pacemaker.
• Perform physical activity during the 48 hours prior to data collection.
• Contraindications of dry needling such as: Belonephobia, history of abnormal reaction to the puncture or injection, anticoagulant treatment or thrombocytopenia, lymphedema over the area of intervention, severely compromised immune system, vascular diseases, diabetes mellitus, pregnancy, epilepsy, allergy to metals or that the intervention area has wounds, scars, tattoos, or stains.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Другое

Центры проведения

Испания · 1 центр

• Sergio Montero Navarro — Elche

Публикации

• Akima H, Yoshiko A, Tomita A, Ando R, Saito A, Ogawa M, Kondo S, Tanaka NI. Relationship between quadriceps echo intensity and functional and morphological characteristics in older men and women. Arch Gerontol Geriatr. 2017 May-Jun;70:105-111. doi: 10.1016/j.archger.2017.01.014. Epub 2017 Jan 20. PMID 28126635
• Young HJ, Jenkins NT, Zhao Q, Mccully KK. Measurement of intramuscular fat by muscle echo intensity. Muscle Nerve. 2015 Dec;52(6):963-71. doi: 10.1002/mus.24656. Epub 2015 Sep 7. PMID 25787260
• Pillen S, Tak RO, Zwarts MJ, Lammens MM, Verrijp KN, Arts IM, van der Laak JA, Hoogerbrugge PM, van Engelen BG, Verrips A. Skeletal muscle ultrasound: correlation between fibrous tissue and echo intensity. Ultrasound Med Biol. 2009 Mar;35(3):443-6. doi: 10.1016/j.ultrasmedbio.2008.09.016. Epub 2008 Dec 10. PMID 19081667
• Teixeira CA, Alvarenga AV, Cortela G, von Kruger MA, Pereira WC. Feasibility of non-invasive temperature estimation by the assessment of the average gray-level content of B-mode images. Ultrasonics. 2014 Aug;54(6):1692-702. doi: 10.1016/j.ultras.2014.02.021. Epub 2014 Mar 1. PMID 24630851
• Pinto MD, Silveira Pinto R, Nosaka K, Blazevich AJ. Do Intramuscular Temperature and Fascicle Angle Affect Ultrasound Echo Intensity Values? Med Sci Sports Exerc. 2023 Apr 1;55(4):740-750. doi: 10.1249/MSS.0000000000003082. Epub 2022 Nov 8. PMID 36355345
• Kenny GP, Reardon FD, Zaleski W, Reardon ML, Haman F, Ducharme MB. Muscle temperature transients before, during, and after exercise measured using an intramuscular multisensor probe. J Appl Physiol (1985). 2003 Jun;94(6):2350-7. doi: 10.1152/japplphysiol.01107.2002. Epub 2003 Feb 21. PMID 12598487

Идентификаторы

NCT: NCT06145646 · CEEI23_453

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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