Kidney and Pregnancy Registry

Обзор

Maternal physiological adaptation to pregnancy plays an important role in the smooth progress of the pregnancy and the healthy growth of the fetus. This physiological adaptation takes place at the level of several organs, including the kidney. Physiological changes during a normal pregnancy take place at the anatomical, glomerular and tubular level. In the event of pre-existing kidney damage (glomerular and tubular diseases, stone disease, high blood pressure (hypertension) etc...) these adaptations will not be optimal. This will have implications for: * the course of the pregnancy with the occurrence of feto-maternal complications: miscarriages, pre-eclampsia, intrauterine growth retardation (IUGR), low birth weight, prematurity. The risk of feto-maternal complications increases with the degree of renal failure or with certain pathologies such as lupus. * progression of kidney disease Some maternal complications have long-term implications: preeclampsia is associated with a high risk of subsequent cardiovascular and renal complications. Pregnancies in these patients are high-risk pregnancies and require specialized management by an experienced group of gynecologists and nephrologists. The creation of a retrospective and prospective register by collecting demographic, clinical, biological, radiological and genetic data concerning patients at each consultation within the CHU Brugmann Hospital will allow: * to establish the epidemiological and clinico-biological characteristics of the patients followed at the Kidney and Pregnancy Clinic at the CHU Brugmann Hospital * to analyze the risk factors for feto-maternal complications * to analyze the risk factors for the occurrence of subsequent cardio-renal pathologies in patients who have had preeclampsia or an event during their pregnancy * to identify patients who will need specialized genetic testing

Вмешательства

• Другое Data extraction from medical files
  Data extraction from medical files

Первичные конечные точки

• Epidemiological characteristics of patients [Срок оценки: 20 years]
• Clinico-biological characteristics of patients [Срок оценки: 20 years]
• Risk factors for feto-maternal complications [Срок оценки: 20 years]
• Risk factors for cardio-renal pathologies [Срок оценки: 20 years]
• Need for genetic testing [Срок оценки: 20 years]

Критерии участия

Критерии включения

• Pre-conception consultations

Woman of childbearing age with:

• Renal damage (glomerular, tubular disease, renal lithiasis, systemic disease, metabolic diseases, congenital diseases, etc.)
• Hematological disorders (sickle cell disease)
• Kidney transplantation
• High blood pressure (hypertension)
• Pre-kidney transplant assessment in progress for discussion of contraception and pregnancy after kidney transplantation
• Preeclampsia
• Multiple miscarriages
• IUGR and low birth weight in the fetus
• Family history of kidney disease
• Peri-gravid consultations

Pregnant women with

• Pre-existing kidney damage
• De novo renal failure (IR)
• Proteinuria
• Hematuria
• Chronic hypertension
• Pregnancy hypertension
• Renal lithiasis
• Postpartum consultations

Postpartum women with

• Early/late pre-eclampsia
• Eclampsia / Hemolysis Elevated Liver enzymes Low Platelet (HELLP) syndrome
• Pregnancy hypertension
• Postpartum hemorrhage
• De novo renal failure postpartum

Критерии исключения

Male patients Menopausal patients

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Бельгия · 1 центр

• CHU Brugmann — Brussels

Идентификаторы

NCT: NCT06067867 · CHUB-BrugKidPreg Reg

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗