Multimodal Computed Tomography in Patients With Acute Hemorrhagic Stroke
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Multimodal CT.
- Кому может быть актуально
- Состояния в реестре: Acute Hemorrhagic Stroke. Базовые параметры: 18 лет — 85 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Multimodal Computed Tomography in Patients With Acute Hemorrhagic Stroke (MCTAHS)
Обзор
Acute hemorrhagic stroke is a series of neurosurgical diseases characterized by bleeding with high morbidity and mortality. It accounts for about 20% of all strokes worldwide and mainly includes subtypes such as intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). Multimodal computed tomography including non-contrast computed tomography, computed tomography angiography and computed tomography perfusion, is of great important in understanding pathophysiological changes, evaluating prognosis and guiding interventions in these diseases.
Подробное описание
Study overview: The data of the population in the MACTAHS study will be prospectively collected. The CT strategies for acute hemorrhagic stroke are mainly three categories: non-contrast computed tomography, computed tomography angiography and computed tomography perfusion. Each participants will be followed at least until 1 year after discharge. Finally, investigators will clarify the prognostic value of multimodal CT for patients with acute hemorrhagic stroke.
Sample size: About 10000 patients will be enrolled in this study. All the population will be expected to undergo non-contrast computed tomography, computed tomography angiography and computed tomography perfusion.
Study endpoints: Neurological functional outcomes, delayed ischemia and infarction, recurrent bleeding, cognition and emotional dysfunction, systemic in-hospital systemic complications, rehabilitation and recovery status will be evaluated and follow-up would be completed.
Вмешательства
- Устройство Multimodal CT
Non-contrast computed tomography, computed tomography angiography and computed tomography perfusion
Первичные конечные точки
- modified Rankin Scale (mRS) [Срок оценки: At 3/6/12 months after onset]
Вторичные конечные точки (12)
- Mortality rate [Срок оценки: At 12 months after onset]
- Total time spent on the intensive care unit (ICU)/stroke unit [Срок оценки: After treatment (max 60 days)]
- Non-neurological systemic complications [Срок оценки: After onset (max 60 days)]
- Delayed infarction [Срок оценки: After onset (max 30 days)]
- Delayed ischemia [Срок оценки: After onset (max 30 days)]
- Hematoma expansion in intracerebral hemorrhage [Срок оценки: 24-48 hours from symptom onset]
- Recurrence of intracerebral hemorrhage [Срок оценки: 90 days from symptom onset]
- Rebleeding of subarachnoid hemorrhage [Срок оценки: After onset (max 7 days)]
- Montreal Cognitive Assessment Scale (MoCA) [Срок оценки: At 3/6/12 months after onset]
- Mini-mental State Examination (MMSE) [Срок оценки: At 3/6/12 months after onset]
- Self-Rating Anxiety Scale (SAS) [Срок оценки: At 3/6/12 months after onset]
- Self-Rating Depression Scale (SDS) [Срок оценки: At 3/6/12 months after onset]
Критерии участия
Критерии включения
- age ≥ 18, ≤ 85 years;
- presence with hemorrhagic stroke
Критерии исключения
- with a history of previous history of ischemic/hemorrhagic stroke;
- admission to the emergency department more than a week after symptom onset;
- serious medical history or existing comorbidities;
- physical disability due to previous diseases;
- prior treatment such as external ventricular drainage, digital subtraction angiography and lumbar puncture in other institution;
- poor original image quality;
- incomplete follow-up.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Китай · 1 центр
- Beijing Tiantan Hospital — Пекин
Идентификаторы
NCT: NCT06061185 · KY 2024-007-02