Идёт набор NCT06047561

The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme

— Наблюдательное Aortic Stenosis

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: PET-CT.
Кому может быть актуально: Состояния в реестре: Aortic Stenosis. Базовые параметры: от 50 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Великобритания
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement. Participants will undergo transthoracic echocardiography every 6 months, with annual visits for state-of-the-art scanning techniques including positron-emission tomography combined with computed tomography or magnetic resonance imaging with radiotracers designed to look at disease processes including fibrosis, calcification, inflammation and thrombosis activity.

Подробное описание

This will be an observational cohort study using existing and prospectively recruited cohorts for both cross-sectional and longitudinal comparison across the spectrum of aortic stenosis severity. For existing cohorts of patients who have previously undergone research assessments, we will invite them for repeated assessments.

Participants will be reviewed every 6 months in the Clinical Research Facility (CRF) over a 4-year period. They will undergo clinical assessment, blood sampling, transthoracic echocardiography and advanced imaging annually including CT angiography, magnetic resonance and positron emission tomography (PET).

Вмешательства

Лучевая терапия PET-CT
PET combined with CT or MRI

Первичные конечные точки

Haemodynamic aortic valve disease progression. [Срок оценки: 4 years]

Вторичные конечные точки (1)

Inflammatory, thrombotic, fibrotic and calcific aortic valve disease progression. [Срок оценки: 4 years]

Критерии участия

Критерии включения

Male or female aged >50 years
Provision of informed consent prior to any study specific procedures
Patients with bioprosthetic aortic valve replacements, including both surgically and transcatheter implanted valves
Patients with severe aortic stenosis (peak velocity >4.0 m/s; previously recruited patients)
Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s; new prospectively recruited patients)
Patients with mild aortic stenosis (peak velocity 2.5-2.9 m/s; new prospectively recruited patients)
Patients with aortic sclerosis (tri-leaflet thickened aortic valve with no obstruction of ventricular outflow)
Age and sex-matched healthy volunteers