Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: diagnosed and treated reasonably according to the clinical guidelines and clinical pathways.
- Кому может быть актуально
- Состояния в реестре: Pituitary Adenoma, Neuroendocrine Tumors. Базовые параметры: 18 лет — 70 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Обзор
As the clinical manifestations of pituitary neuroendocrine tumors vary greatly, 2.7-15% of them are resistant to conventional treatments such as surgery, drug therapy and radiotherapy, and often relapse or regrow in the early postoperative period, which is invasive and has a poor prognosis. Therefore, it is important to find imaging, histological or serum molecular markers for early prediction of the invasiveness and clinical prognosis of pituitary neuroendocrine tumors. The aim of this study is to observe the changes of biomarkers and imaging features in serum or tissues of pituitary neuroendocrine tumors during the course of disease and treatment, and to explore the biomarkers and imaging features that can predict the proliferation, progression and recurrence risk of pituitary neuroendocrine tumors after medical or surgical treatment.
Вмешательства
- Другое diagnosed and treated reasonably according to the clinical guidelines and clinical pathways
The clinical data and biological specimens of the selected patients were collected, and the patients were diagnosed and treated reasonably according to the clinical guidelines and clinical pathways. The prognosis and outcome of the disease within 5 years after discharge were observed.
Первичные конечные точки
- Disease progression or recurrence after surgery [Срок оценки: up to 5 years]
Критерии участия
Критерии включения
Patients with pituitary neuroendocrine tumors: pituitary adenoma was diagnosed by clinical imaging, with or without pituitary hormone secretion function was confirmed by pituitary hormone detection.
Критерии исключения
- Previous pathological specimen suggested pituitary carcinoma.
- always have received radiation and chemotherapy or immune and targeted therapy of the patients.
- with known genetic syndrome can cause excessive secretion of hormones (such as Carney syndrome, McCune - Albright syndrome, multiple endocrine neoplasia type 1, acute interstitial pneumonia) patients.
- there are ectopic neuroendocrine tumor patients.
- within one month before the screening for major surgery, or within 3 months before screening for patients with sphenoid pituitary surgery.
- crisis of gland function (the pituitary gland, thyroid crisis, adrenal crisis).
- peripheral glands or other solid tumors in patients with severe disease or blood system.
- serious organ damage such as heart, kidney, liver, etc.
- with severe mental or nervous system disease.
- serious high blood glucose or poorly controlled hypertension or emergency patients.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Китай · 1 центр
- endocrinology department of the first affiliated hospital of Sun Yat-sen University — Гуанчжоу
Идентификаторы
NCT: NCT06015802 · 2021450