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Идёт набор NCT06001073

Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics

— Наблюдательное Coronary Artery Disease Arrhythmias, Cardiac Heart Valve Diseases Aortic Dissection

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Observational; No Interventions were given..
Кому может быть актуально
Состояния в реестре: Coronary Artery Disease, Arrhythmias, Cardiac, Heart Valve Diseases, Aortic Dissection. Базовые параметры: 3 лет — 80 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Китай
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics (PROSPECT): a National, Multicenter, Retrospective-prospective, Cohort Study

Обзор

The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.

Подробное описание

Cardiovascular and cerebrovascular diseases refer to ischemic and hemorrhagic diseases of the heart, brain and body tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. It is one of the major public health problems in the world. The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.

Вмешательства

  • Другое Observational; No Interventions were given.
    Observational; No Interventions were given.

Первичные конечные точки

  • Change of MACCE [Срок оценки: Through study completion, up to 5 years.]
Вторичные конечные точки (4)
  • Change of all-cause mortality [Срок оценки: Through study completion, up to 5 years.]
  • Incidence of myocardial infarction [Срок оценки: Through study completion, up to 5 years.]
  • Incidence of coronary revascularization. [Срок оценки: Through study completion, up to 5 years.]
  • Incidence of stroke [Срок оценки: Through study completion, up to 5 years.]

Критерии участия

Критерии включения

  • Patients who are regularly visited and followed up in the appropriate patient; department.
  • All patients met at least one of the following diagnostic criteria for cardiovascular and cerebrovascular diseases:
  • coronary artery disease group;
  • arrhythmia group;
  • heart valve disease group;
  • aortic dissection group;
  • cardiac masses group;
  • myocarditis group;
  • hypertension group;
  • cardiomyopathy group;
  • structural heart disease group;
  • ischemic cerebrovascular disease group;
  • hemorrhagic cerebrovascular disease group;
  • intracranial space occupying lesion group.

Критерии исключения

  • Age <3 years or >80 years old;
  • Pregnant and lactating women;
  • The patient declined to provide informed consent to participate in the study;
  • None of the above was met, but the patient was temporarily unable to sign the informed consent form due to coma and other reasons, and no legal representative signed it instead. Depending on the patient's condition, the patient may not be able to regain consciousness and sign the informed consent form.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Китай · 1 центр
  • First Affiliated Hospital of Xian Jiantong University — Сиань

Идентификаторы

NCT: NCT06001073 · XJTU1AF2023LSK-353

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗