Deconstructing Post Stroke Hemiparesis
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Stroke. Базовые параметры: 18 лет — 90 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- США
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Deconstructing Post Stroke Hemiparesis for Precision Neurorehabilitation
Обзор
TRACTs (DeconsTructing Post StRoke HemipAresis for PreCision NeurorehabiliTation) is a single timepoint study that aims to deconstruct post-stroke deficits of the upper extremity into distinct components and relate these components to brain anatomy and physiology.
Подробное описание
Veterans will be recruited through the Providence Veterans Affairs Medical Center and will have research visits at the Providence VA Center for Neurorestoration and Neurotechnology (CfNN, centerforneuro.org). The research visits will span two to three days. The study will involve motor outcome measures, magnetic resonance imaging of the brain, and transcranial magnetic stimulation. The goal of this study is to associate post-stroke deficits of the upper extremity with brain anatomy and physiology.
Первичные конечные точки
- Fugl-Meyer Arm Motor Assessment [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
Вторичные конечные точки (12)
- Edinburgh Handedness Inventory [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Action Research Arm Test (ARAT) [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Modified Ashworth Scale [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Nottingham Sensory Assessment (Erasmus MC) [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- National Institute of Health Stroke Scale [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Montreal Cognitive Assessment (MoCA) [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Patient Health Questionnaire 9 (PHQ-9) [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- History of TBI [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Barthel Index [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Modified Rankin Scale [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Defense and Veterans Pain Rating Scale [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
- Manual Muscle Testing [Срок оценки: Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent]
Критерии участия
Критерии включения
- Diagnosis of a unilateral ischemic stroke occurring >6 months prior as documented in medical chart
- Upper extremity motor impairment as measured by Fugl-Meyer Upper Extremity Assessment ≤60
- Ability to follow simple instructions in English
Критерии исключения
- Greater than moderate difficulty using the arm and hand pre-dating the stroke as assessed by the questions adapted from the QuickDASH outcome measure score on any question >= 3, which measures physical function and symptoms in people with difficulty using the arm and hand.
- Visual or auditory disorders resulting in the inability to see or hear, respectively, the stimuli presented as part of research sessions
- Inability to maintain a seated position for at least one hour
- Standard MRI exclusion (e.g., significant claustrophobia or inability to tolerate loud noises, cardiac pacemaker (unless MRI-safe), implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord)
- Standard (single-pulse) TMS exclusion which include (in addition to those listed for MRI) pregnancy/lactation/planning to become pregnant during the study, seizure disorder, and primary or secondary CNS tumors
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
США · 1 центр
- Providence VA Medical Center — Providence
Идентификаторы
NCT: NCT05993221 · 1689966