Sevoflurane General Anesthetic and Spatial Memory in Humans
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Surgery/general anesthesia.
- Кому может быть актуально
- Состояния в реестре: Spatial Memory Disorder. Базовые параметры: 30 лет — 50 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Чили
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Study of the Effect of Sevoflurane General Anesthetic on Spatial Memory in Humans
Обзор
The goal of this observational study is to learn about the effect of general anesthetic on spatial memory in adults who will undergo to an elective surgery. The main question it aims to answer is: • A surgical event under general anesthesia with sevoflurane transiently impairs spatial memory in humans and induces an increase in inflammatory cytokines. Participants will perform a virtual maze test and plasma samples will be taken before and after surgery.
Подробное описание
Postoperative cognitive dysfunction (POCD) occurs after a surgical event under general anesthesia and is characterized by a decline in one or more cognitive functions. POCD is defined as delayed neurocognitive recovery if it takes place within the first 30 days, if it exceeds that time it is known as postoperative neurocognitive disorder. The pathogenesis of this dysfunction is not entirely clear. However, the most accepted hypothesis would be neuroinflammatory, which would take place due to the contribution of inflammatory factors typical of surgical trauma under general anesthesia, with anesthetics such as sevoflurane. Consequently, one of the areas most susceptible to this inflammatory environment would be the hippocampus, a structure responsible for learning and memory. Spatial memory is responsible for encoding and retrieving information about the environment and spatial orientation. To confirm this hypothesis, an elective laparoscopic cholecystectomy under general anesthesia with sevoflurane, plasma measurement of cytokines interleukin-1beta and tumor necrosis factor-alpha and virtual navigation tests will be performed before and after an elective laparoscopic cholecystectomy under general anesthesia with sevoflurane, in order to establish a correlation between the inflammatory component and performance in the virtual navigation test. The above will allow us to elucidate the possible occurrence of a delayed neurocognitive recovery related to spatial memory in middle-aged individuals, providing new background related to an age group that has been little studied, with a non-minor incidence (30%), where the evident concern arises for being a population exposed to activities or environments of greater risk, linked to work, sport, driving, among others. This finding will guide the doctor and the patient to decide or take the necessary safeguards when proceeding with a surgical intervention in the middle-aged population.
Вмешательства
- Процедура Surgery/general anesthesia
Adult patients between the ages of 30 and 50 who are to undergo elective surgery under general anesthesia will have their spatial memory tested and interleukin 1beta and alpha tumor necrosis measured before and after surgery.
Первичные конечные точки
- Virtual spatial memory [Срок оценки: 1th day after surgery]
Вторичные конечные точки (8)
- Interleukin-1beta [Срок оценки: 1st day after surgery]
- Interleukin-1beta [Срок оценки: 7th day after surgery]
- Interleukin-1beta [Срок оценки: 30th day after surgery]
- Tumor necrosis factor alpha [Срок оценки: 1st day after surgery]
- Tumor necrosis factor alpha [Срок оценки: 7th day after surgery]
- Tumor necrosis factor alpha [Срок оценки: 30th day after surgery]
- Virtual spatial memory [Срок оценки: 7st day after surgery]
- Virtual spatial memory [Срок оценки: 30th day after surgery]
Критерии участия
Критерии включения
- Candidate for elective laparoscopic surgery of cholecystectomy.
- Age 30 to 50 years.
Критерии исключения
- Visual or hearing difficulties.
- Malignant hyperthermia.
- Being treated with centrally acting drugs, such as anxiolytics, antidepressants, antipsychotics, anticonvulsants, anticholinergics, and first-generation antihistamines.
- Present a disorder of the sphere of neuropsychiatry
- Substance abuse disorder.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Чили · 2 центра
- Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chil — Santiago
- Hospital Clinico de la Universidad de Chile — Santiago
Идентификаторы
NCT: NCT05991817 · OAIC: 1328/23