Neurofeedback Training for PD

Официальное название

EEG- or STN LFP-based Neurofeedback Training for Improving Motor Functions in Parkinson's Disease

Обзор

The goal of this clinical trial is to test neurofeedback training in both people with Parkinson's disease and healthy control. The main questions it aims to answer are: * To demonstrate that EEG based or STN LFP based neurofeedback can help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively; * To evaluate the learning effect of the neurofeedback training with multiple training sessions Patient participants will be asked to receive the research intervention called neurofeedback training for maximal three separate sessions. During the intervention, the participants will also be asked to press a pinch meter as fast as possible in order to measure the reaction time, meanwhile, different type of brain signals will be recorded. . This will be a within-subject cross-over study contrasting the effect of the neurofeedback training and no training.

Вмешательства

• Поведенческое Neurofeedback training
  Features related to PD symptoms will be extracted from the brain recordings in real-time and used to drive a visual cursor on a computer screen placed in front of the participant, while the participant will be asked to try to control the cursor by regulating their brain signals.

Первичные конечные точки

• The feasibility of using EEG-based neurofeedback to help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively. [Срок оценки: 10 days]
• Learning effect of the neurofeedback training with multiple training sessions [Срок оценки: 10 days]

Вторичные конечные точки (6)

• The effect of EEG-based neurofeedback on motor performance quantified as reaction time in patients with Parkinson's disease [Срок оценки: 10 days]
• The effect of EEG-based neurofeedback on motor performance quantified as peak movement velocity in patients with Parkinson's disease [Срок оценки: 10 days]
• The effect of EEG-based neurofeedback on parkinsonian tremor [Срок оценки: 10 days]
• The effect of EEG-based neurofeedback on motor Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score [Срок оценки: 10 days]
• The effect of EEG-based neurofeedback on motor performance quantified as reaction time in healthy age-matched control [Срок оценки: 10 days]
• The peak movement velocity during the cued motor task will be measured, and compared between training and no-training conditions in healthy age-matched control group. [Срок оценки: 10 days]

Критерии участия

Критерии включения

• Participants with symptomatic Parkinson's disease or age-matched healthy control
• Adequate understanding of verbal explanation or written information given in English
• Able and willing to give informed consent.
• Normal or corrected-to-normal vision

Критерии исключения

• Lack of capacity to consent (judged by the researcher taking consent as not having sufficient mental capacity to understand the study and its requirements)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT05987865 · 249990

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗