Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest

Each year, 50.000 out-of-hospital cardiac arrest (OHCA) occur in France. Acute myocardial infarction (AMI) is one of the most frequent etiology of OHCA. When a cardiac arrest is due to a ST-elevation myocardial infarction (STEMI), a percutaneous coronary intervention (PCI) is realized in emergency. However, without ST-elevation, PCI timing is unclear. 2020 European Society Recommandations suggest that PCI should not be realized in emergency, based on Lemkes and al. clinical trial. But there is scarce evidence about the exact timing to realize PCI. Electrocardiogram, troponin level, and echocardiography are unprecise to rule-out an ischemic etiology of cardiac arrest.

A brain CT-scan and a CT-pulmonary angiogram are recommended in first place, to identify the etiology of the cardiac arrest if there is no ST-elevation nor obvious causes. Nevertheless, in the absence of scanographic abnormality, a differed coronary angiogram should be realized.

We suggest that coronary CT angiogram (CCTA) and coronary calcium score (CCS) are feasible in the first days of hospitalization, and could rule-out a coronary artery disease (CAD). The aim of the study is to avoid an invasive coronary exploration, and to have a quick answer about anti-thrombotic treatments management.

• Diagnostic accuracy of Coronary Computerized Tomographic Angiogram to rule-out a coronary stenosis > 70% [Срок оценки: During hospitalization (maximum 7 days from ICU admission)]
• Cororany calcium score associated with coronary stenosis between 50% and 70% [Срок оценки: During hospitalization (maximum 7 days from ICU admission)]
• Diagnostic accuracy of Coronary Computerized Tomographic Angiogram associated with Coronary Calcium Score compared to CCTA performance alone [Срок оценки: During hospitalization (maximum 7 days from ICU admission)]
• Incidence of contrast associated acute kidney injury [Срок оценки: Day 15]
• Comparison of contrast volume between CCTA and percutaneous coronary intervention [Срок оценки: During hospitalization (maximum 7 days from ICU admission)]
• Comparison of radiation dose between CCTA and percutaneous coronary intervention [Срок оценки: During hospitalization (maximum 7 days from ICU admission)]