Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise

Обзор

The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.

Подробное описание

Although nearly half of the population is female, less than 10% of research resources are allocated to understanding how their dynamic physiology impacts athletic readiness, performance, and recovery. The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and the inflammatory environment and quantification of muscle damage.

Вмешательства

• Поведенческое Eccentric leg extension
  Participants will complete a 10 x 10 eccentric leg extension on a Cybex Norm dynamometer. Upon arrival, participants will be asked their perceived readiness to perform on a 11 point numeric rating scale. Before the running protocol a baseline blood sample will be collected, as well as passive and active delayed onset muscle soreness (DOMS), a countermovement jump. Half way through each set (i.e., after the 5th repetition) participants will be asked to rank their level of difficulty on a 11 point

Первичные конечные точки

• Preparedness to perform [Срок оценки: Pre exercise]
• Rating of difficulty [Срок оценки: 30 minutes]
• Inflammatory markers [Срок оценки: Change over time (pre/post, 24 hour, 48 hour)]
• Counter movement jump height [Срок оценки: Change over time (pre/post, 24 hour, 48 hour)]
• Passive Delayed Onset Muscle Soreness (DOMS) [Срок оценки: Change over time (pre/post, 24 hour, 48 hour)]
• Active Delayed Onset Muscle Soreness (DOMS) [Срок оценки: Change over time (pre/post, 24 hour, 48 hour)]

Критерии участия

Критерии включения

• 18-35 years of age
• BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\]
• Not taking contraception or other types of medication that could influence reproductive status
• Regular menstruation
• Non-pregnant
• Medically free from chronic diseases
• Novel to downhill running
• Weight greater than or equal to 110 lbs
• Not taking exogenous hormones
• Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity

Критерии исключения

• Amenorrhea or oligomenorrhea
• Perimenopausal or menopausal
• Recreational or professional trail or downhill runner
• On a form of contraception
• Cardiac disability
• Pacemaker
• Arterial disease
• Uncontrolled hemorrhage
• Blood clots
• Pregnant or trying to become pregnant
• Cancerous lesions
• Sensory or mental impairment
• Unstable fractures
• Weight less than 110 lbs
• Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
• Taking exogenous hormones

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Организация здравоохранения

Центры проведения

США · 1 центр

• Clinical Exercise Research Center — Los Angeles

Идентификаторы

NCT: NCT05934708 · HS-23-00363

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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