Идёт набор NCT05884892

Egyptian Hypertrophic Cardiomyopathy Program

— Наблюдательное Hypertrophic Cardiomyopathy

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально: Состояния в реестре: Hypertrophic Cardiomyopathy. Базовые параметры: Без ограничений · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Египет
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Egyptian HCM program aims at defining incidence, severity, phenotype, genotype and determinants of the disease in Egypt, and providing state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.

Подробное описание

This project aims to:

* Define incidence, severity, phenotype, genotype and determinants of the disease in Egypt. * Characterise the phenotype and genotype of several large cohorts with inherited muscle disease and their relatives. * Provide state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific. * Study the basic mechanisms responsible for the different phenotypes at a molecular and cellular level including genotype-phenotype correlation. * Provide a special focus for studying patients who are genotype positive and phenotype negative which we believe could yield critical data regarding the evolution of the disease. * Develop sophisticated laboratory studies for single cell electrophysiology and immunocytochemistry and others focusing on the explanted human material from the surgical program. * Define the role of microvascular coronary artery in the development and progression of the disease. * Training Egyptian cardiologists, cardiac surgeons and scientists on state-of-the-art diagnosis and management of heart muscle disease including the latest developments in imaging, novel surgical techniques, coronary physiology, next generation sequencing, bioinformatics and cellular electrophysiology.

Первичные конечные точки

Incidence of HCM in Egypt [Срок оценки: through study completion, an average of 5 year]
Determinants of clinical severity of HCM in Egypt [Срок оценки: through study completion, an average of 1 follow-up every year, and an average of 5 follow-ups throughout the study duration]
Determinants of cardiac phenotype severity of HCM in Egypt [Срок оценки: through study completion, an average of 1 follow-up every year, and an average of 5 follow-ups throughout the study duration]
Determinant of genotype severity of HCM in Egypt [Срок оценки: through study completion, at least once at the time of inclusion]
Study the basic mechanisms responsible for the HCM in Egypt [Срок оценки: through study completion, at least once at the time of inclusion, or]

Критерии участия

Критерии включения

All patients diagnosed with hypertrophic cardiomyopathy (index patients) who are willing and consented to participate in the registry.
All family members of index patients who are willing and consented to participate in the registry.