Fit to Fight Childhood Cancer

The longitudinal, prospective and monocentric cohort study at the University Medical Centre Mainz is based on the Europe-wide, multicentre FORTEe study \[NCT05289739\]. The Kolibri study aims to complement the FORTEe trial. Kolibri allows the inclusion of patients who are not receiving chemotherapy and/or radiotherapy or who are undergoing oncological aftercare.

The longitudinal design of the study will allow the effects of exercise therapy on cancer-related fatigue, health-related quality of life and other psychosocial outcomes, as well as on physical function, to be monitored over the course of oncological treatment, and will provide conclusions about the effectiveness and benefits of exercise therapy. This will enable the establishment and improvement of exercise therapy protocols, as the effects of the exercise dose applied can be observed and compared over time.

The project will also validate and test the reliability of the Mainz Resilience Score in childhood cancer (MRScc) developed in the FORTEe project. The aim is to establish a validated questionnaire to assess resilience in children and adolescents with cancer, as no questionnaires are currently available.

• Change from baseline in the score of resilience (measured by Mainzer Resilience Scale for childhood cancer (MRScc)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the score of resilience (measured by the Brief Resilience Scale (BRS)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the score of resilience (measured by the Child & Youth Resilience Measure-Revised (CYRM-R)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in general self-efficacy score at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the score of physical exercise self-efficacy at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the risk status of pain-related outcomes at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the subjective pain perception (measured with the face pain scale - revised (FPS-R)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the subjective pain perception (measured via visual analog scale (VAS)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the fear of pain (parents) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the score of pain vigilance and awareness at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the physical activity level (measured by the Modifed Recent Physical Activity Questionnaire (mRPAQ)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]
• Change from baseline in the physical activity level (measured by the Modified Youth Physical Activity Questionnaire (mYPAQ)) at yearly intervals up to 5 years [Срок оценки: baseline, after 1 year, after 2 years, after 3 years, after 4 years, after 5 years]