Implementation of Anal Cancer Screening and Treatment in Nigeria
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Enhanced Training on screening and treatment of HSIL (e-STH).
- Кому может быть актуально
- Состояния в реестре: Education, Medical. Базовые параметры: Без ограничений · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Nigeria
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Integrated Model for the Prevention of Anal Cancer Using Screen and Treat for High-grade Intraepithelial Lesions (IMPACT)
Обзор
The study is a feasibility pilot trial testing 2 types of training protocols on a single physician. The first training protocol is the current standard and was developed in high-income settings. The second training protocol will be developed so tailored to the Nigerian setting. Investigators will test if the physician performs differently in their ability to conduct anal cancer screening and treatment between the 2 training protocols.
Подробное описание
In Aim 1, anal cancer screening and treatment based on standard training protocols of how to screen and treat high-grade intraepithelial lesions (HSILs) to prevent anal cancer as developed in high-income settings will be conducted. Investigators will identify barriers and facilitators with learning the procedure with standard training using the Consolidated Framework for Implementation Research (CFIR). In Aim 2, Investigators will identify strategies to modify the standard training to improve learning on a complicated procedure using the Expert Recommendations for Implementing Change (ERIC) framework. An implementation science committee will co-design and develop an enhanced training on Screening and Treatment of HSIL (e-STH) by matching the barriers identified with CFIR with strategies in ERIC. Investigators will then take an iterative improvement approach to test and refine the implementation of the enhanced training intervention to ensure that HSIL screening and treatment is readily adopted and maintained as part of HIV care. In Aim 3 (CLINICAL TRIAL AIM), Investigators will conduct a Hybrid Type 2 trial using an interrupted time series design to monitor and evaluate outcomes along the implementation continuum. The trial will be conducted at a single clinic to minimize variability. The participant (Physician) will have a pre-period of HSIL screening and treatment for 12 months after standard training. Next, investigators will roll out e-STH for 6 months. Then there will be a post-period of screening for 12 months to evaluate the impact of e-STH. Lastly, there will be 6 months of screening and treatment with minimal involvement of the investigative team to evaluate sustainability.
The study will compare e-STH to standard training in proportion of HSIL detected and treated with secondary outcomes evaluating reach, efficacy, implementation, and sustainability.
Вмешательства
- Поведенческое Enhanced Training on screening and treatment of HSIL (e-STH)
Tailored training developed to overcome key barriers and promote facilitators unique to implementing HSIL screening and treatment. The development will be driven by the implementation science committee over 3 iterations every 4 months for up to a year to refine the adoption of strategies with the greatest breadth to facilitate implementation.
Первичные конечные точки
- Change in HSIL detection [Срок оценки: 12 months and 30 months]
- Change in HSIL treatment [Срок оценки: 12 months and 30 months]
Вторичные конечные точки (4)
- Change in Reach of intended population [Срок оценки: 12 months and 30 months]
- Change in Efficacy of conducting HSIL screening and treatment [Срок оценки: 12 months and 30 months]
- Change in Implementation of HSIL screening and treatment [Срок оценки: 12 months and 30 months]
- Change in Maintenance of HSIL screening and treatment [Срок оценки: 18 months and 36 months]
Критерии участия
Критерии включения
- Possess a medical degree in medical sciences (MBBS or equivalent)
- At least 2-5 years of experience working with clinical HIV/AIDS community
- Must be registered with the medical and dental council of Nigeria
- Possess a current medical practicing license
- Willing to work with the Sexual Gender Minority Community
Критерии исключения
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Распределение
- Нерандомизированное
- Модель
- Последовательный дизайн
- Маскирование
- Открытое
- Основная цель
- Профилактика
Центры проведения
Nigeria · 1 центр
- International Center for Advocacy on Right to Health (ICARH) — Abuja
Идентификаторы
NCT: NCT05817370 · HP-00101383 · U01CA275053