Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC

Официальное название

Neoadjuvant Toripalimab Combined With Chemotherapy in Rare Mutations Stage IIB-IIIB NSCLC

Обзор

Phase II, single-arm, open-label single center study that assess clinical feasibility and safety of 3 cycles neoadjuvant Toripalimab plus chemotherapy in rare mutations stage IIB-IIIB NSCLC followed by optional adjuvant treatment upon investigators' decisions.

Подробное описание

30 eligible patients will be enrolled and 3 cycles of Toripalimab 240mg + chemotherapy (Nab-paclitaxel + carboplatin, or pemetrexed + carboplatin) will be administered. Rare mutations include RET fusions, BRAF (V600E or non-V600E but confirmed driver mutations), ERBB2 exon20 insertion, MET amplification (FISH confirmed) or exon 14 skipping. Dynamic blood samples before, during or after neoadjuvant treatment will be obtained for exploratory analysis. Patients who showed inferior response to neoadjuvant treatment leading to unresectable disease will be scheduled for local radiation or other potential subsequent treatment regarding multidisciplinary discussion. After completion of local treatment (surgery or radiation), patients will be provided with optional adjuvant treatment including chemotherapy or/and rare mutations TKI upon investigators' consideration. The primary objective of the study is pathological complete response (pCR) defined as no residue tumor found in both primary lung cancer and metastatic lymph nodes.

Вмешательства

• Биопрепарат Toripalimab
  240mg Q3W
• Препарат Nab paclitaxel
  135 mg/m2, d1, 8 Q3W
• Препарат Pemetrexed
  500mg/m2, d1 Q3W
• Препарат Carboplatin
  AUC 5, d1 Q3W

Первичные конечные точки

• Pathological Complete Response (pCR) [Срок оценки: pCR will be assessed within 2 weeks after surgery]

Вторичные конечные точки (4)

• Major Pathological Response (MPR) [Срок оценки: MPR will be assessed within 2 weeks after surgery]
• Event-Free Survival (EFS) [Срок оценки: From date of initiation of neoadjuvant treatment to disease progression, reoccurrence, or death due to any cause, up to 36 months.]
• Overall Survival (OS) [Срок оценки: From date of initiation of neoadjuvant treatment to the date of all-cause death, assessed up to 60 months.]
• Adverse Events (AEs) [Срок оценки: From date of initiation of neoadjuvant treatment till treatment discontinuation, assessed up to 14 weeks.]

Критерии участия

Критерии включения

• Age: 18 Years and older
• ECOG physical score 0-1 points; expected survival time ≥ 3 months;
• Pathologically confirmed diagnosis with Stage IIB-IIIB NSCLC which harbored rare driver alteration including RET fusions, BRAF (V600E or non-V600E but confirmed driver mutations), ERBB2 exon20 insertion, MET amplification (FISH confirmed) or exon 14 skipping. Suspected N2 disease should be confirmed by either mediastinoscopy or EBUS. N1 disease could be determined through PET/CT but biopsy of primary lung cancer is needed;
• Lung function capacity capable of tolerating the proposed lung surgery
• Available tissue of tumor for PD-L1 test
• Subjects voluntarily joined the study and signed informed consent, with good compliance to follow-up.

Критерии исключения

• Stage I and stage IV NSCLC;
• Patients who have previously used any other anti-tumor drugs or radiotherapy;
• Large panel NGS indicated sensitive EGFR alteration, ALK fusion, ROS1 fusion or any other driver mutations combined with MDM2/MDM4 amplification;
• Histologically confirmed small cell lung cancer (including lung cancer mixed with small cell lung cancer and non-small cell lung cancer);
• A history of active bleeding within the 6 months before enrollment, or receiving thrombolysis or anticoagulant therapy, or the investigator believes that there is a clear tendency to gastrointestinal bleeding (such as esophageal varices with bleeding risk, local activity) Ulcer lesions, etc.) or active hemoptysis;
• Patients with any underlying disease that investigators consider it may affect patient's prognosis including sever cardiovascular, pulmonary disease or serious infections; Clinically obvious gastrointestinal abnormalities, which may affect the intake, transport or absorption of drugs (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.), or patients with total gastrectomy;
• Known or suspected autoimmune disease with activity. Participants may be enrolled if they have type 1 diabetes, hypothyroidism that requires only hormone replacement therapy, skin diseases that require no systemic treatment (such as purpura, psoriasis, or hair loss), or other conditions that are not expected to return without external trigger.
• Patients with active hepatitis B (positive for HBsAg) or hepatitis C (positive for HCV RNA).
• Patients with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)
• Patients with other active malignancies within five years
• Pregnant or lactating women; those who have fertility are unwilling or unable to take effective contraceptive measures;
• Patients with low compliance or willingness to take the drugs and surveillance.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy — Guanzhou

Идентификаторы

NCT: NCT05800340 · NEORM

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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