Abnormal Eating and Taste Perception in Subjects With Obesity

Официальное название

Food Addiction, Binge Eating Disorder and Taste Perception in Subjects With Obesity

Обзор

The identification of safe and effective strategies for weight loss and long-term maintenance is critical to reduce the alarming prevalence of obesity worldwide and mitigate obesity-associated health risks. Specifically, Binge Eating (BE) and Food Addiction (FA) behaviors are well known causes of failed weight loss and weight regain. The definitions of their clinical phenotypes are currently evolving. Recent evidence suggests that food choices, behavior and reward may be driven also by taste perception. The hypothesis of this study is that subjects with dysfunctional eating behavior have different taste thresholds compared to obese subjects without eating disorders, and that this characteristic influences food choice and eating behavior. Identifying a difference in the taste thresholds between obese with and without eating disorder will allow us to understand why certain individuals over-consume or binge on densely caloric foods and to give them a tailored dietary treatment so as to maintain weight loss for a long time. The Binge eating and Food Addiction is assessed using Binge Eating Scale and Yale Food Addiction Scale 2.0. Subjects with obesity recruited are divided in 4 groups: without eating disorder, with food addiction (FA), with binge eating (BE) and with FA + BE. In these groups sweet and salty taste will be measured with the 3-Alternative-Forced-Choice method.

Первичные конечные точки

• sweet taste recognition threshold [Срок оценки: baseline]
• salt taste recognition threshold [Срок оценки: baseline]

Вторичные конечные точки (3)

• prevalence of binge eating (BE) [Срок оценки: baseline]
• prevalence of Food Addiction (FA) [Срок оценки: baseline]
• prevalence of Food Addiction (FA) + Binge Eating (BE) [Срок оценки: baseline]

Критерии участия

Критерии включения

• BMI>30 kg/m2 and <45 kg/m2

Критерии исключения

• uncooperative patients
• heavy smokers
• pregnancy or recent (in the last 6 months) childbirth
• thyroid disorders
• presence of endocrine abnormalities associated with obesity
• current or recent oral, nasal or sinus infections
• major psychiatric disorder even in pharmacological compensation
• patients who had undergone bariatric surgery

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Италия · 1 центр

• Istituto Auxologico Italiano — Milan

Публикации

• Aloi M, Rania M, Rodriguez Munoz RC, Jimenez Murcia S, Fernandez-Aranda F, De Fazio P, Segura-Garcia C. Validation of the Italian version of the Yale Food Addiction Scale 2.0 (I-YFAS 2.0) in a sample of undergraduate students. Eat Weight Disord. 2017 Sep;22(3):527-533. doi: 10.1007/s40519-017-0421-x. Epub 2017 Aug 5. PMID 28780748
• Arlt JM, Smutzer GS, Chen EY. Taste assessment in normal weight and overweight individuals with co-occurring Binge Eating Disorder. Appetite. 2017 Jun 1;113:239-245. doi: 10.1016/j.appet.2017.02.034. Epub 2017 Feb 24. PMID 28242311
• Bertoli S, Leone A, Ponissi V, Bedogni G, Beggio V, Strepparava MG, Battezzati A. Prevalence of and risk factors for binge eating behaviour in 6930 adults starting a weight loss or maintenance programme. Public Health Nutr. 2016 Jan;19(1):71-7. doi: 10.1017/S1368980015001068. Epub 2015 May 11. PMID 25958773
• Proserpio C, Laureati M, Bertoli S, Battezzati A, Pagliarini E. Determinants of Obesity in Italian Adults: The Role of Taste Sensitivity, Food Liking, and Food Neophobia. Chem Senses. 2016 Feb;41(2):169-76. doi: 10.1093/chemse/bjv072. Epub 2015 Dec 15. PMID 26671250

Идентификаторы

NCT: NCT05772052 · 43C002

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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